Dimethyl-phenyl-{(Z)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-hept-5-en-1-ynyl}-silane

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Chemical Name:Dimethyl-phenyl-{(Z)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-hept-5-en-1-ynyl}-silane
CAS No.:864908-92-9
Molecular Formula:C₂₂H₃₂O₂Si
Molecular Weight:356.58
Hs Code.:

Synonyms:Dimethyl-phenyl-{(Z)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-hept-5-en-1-ynyl}-silane

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Chemical Property of Dimethyl-phenyl-{(Z)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-hept-5-en-1-ynyl}-silane

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Technology Process of Dimethyl-phenyl-{(Z)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-hept-5-en-1-ynyl}-silane

There total 4 articles about Dimethyl-phenyl-{(Z)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-hept-5-en-1-ynyl}-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 198411-11-9
5-dimethylphenylsilyl-1-(2-tetrahydropyranyloxy)-4-pentyne

: 4784-77-4,29576-14-5,39616-19-8
(Z)-crotyl bromide

: 864908-92-9
Dimethyl-phenyl-{(Z)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-hept-5-en-1-ynyl}-silane

Guidance literature:: 5-dimethylphenylsilyl-1-(2-tetrahydropyranyloxy)-4-pentyne; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In tetrahydrofuran; cooling;

(Z)-crotyl bromide; In tetrahydrofuran;
DOI:10.1055/s-2005-864825

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 864908-92-9
Dimethyl-phenyl-{(Z)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-hept-5-en-1-ynyl}-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / p-TsOH / CH₂Cl₂ / 20 °C

2.1: 90 percent / n-BuLi / tetrahydrofuran / -78 °C

3.1: n-BuLi; t-BuLi; TMEDA / tetrahydrofuran / cooling

3.2: 60 percent / tetrahydrofuran

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2005-864825

Reference yield:

: 62992-46-5
1-(tetrahydropyranyloxy)-4-pentyn

: 864908-92-9
Dimethyl-phenyl-{(Z)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-hept-5-en-1-ynyl}-silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / n-BuLi / tetrahydrofuran / -78 °C

2.1: n-BuLi; t-BuLi; TMEDA / tetrahydrofuran / cooling

2.2: 60 percent / tetrahydrofuran

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In tetrahydrofuran;
DOI:10.1055/s-2005-864825