tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2-phenyl-1,3-dioxan-4-yl)acetate

Base Information

Chemical Name:tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2-phenyl-1,3-dioxan-4-yl)acetate
CAS No.:1235588-93-8
Molecular Formula:C₃₃H₄₂O₅Si
Molecular Weight:546.779
Hs Code.:

Synonyms:tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2-phenyl-1,3-dioxan-4-yl)acetate

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Chemical Property of tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2-phenyl-1,3-dioxan-4-yl)acetate

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Technology Process of tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2-phenyl-1,3-dioxan-4-yl)acetate

There total 1 articles about tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2-phenyl-1,3-dioxan-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1125-88-8
benzaldehyde dimethyl acetal

: 124655-07-8
(3R,5S)-tert-butyl 6-(tert-butyldiphenylsilyloxy)-3,5-dihydroxyhexanoate

: 1235588-93-8
tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2-phenyl-1,3-dioxan-4-yl)acetate

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 6h;

Reference yield: 98.0%

: 1235588-93-8
tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2-phenyl-1,3-dioxan-4-yl)acetate

: 1235588-94-9
tert-butyl 2-((4R,6S)-6-(hydroxymethyl)-2-phenyl-1,3-dioxan-4-yl)acetate

Guidance literature:: tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2-phenyl-1,3-dioxan-4-yl)acetate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h;

With water; sodium carbonate;

Reference yield:

: 1235588-93-8
tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2-phenyl-1,3-dioxan-4-yl)acetate

: 355806-00-7
rosuvastatin tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

2.1: potassium bromide; sodium hydrogencarbonate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / -15 - 20 °C

3.1: potassium carbonate / dimethyl sulfoxide / 1 h / 18 °C

3.2: 5 h / 60 °C

4.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 °C

With hydrogenchloride; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; potassium carbonate; potassium bromide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;