Technology Process of 11-[7-(3,4-diacetoxy-5-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,2,6-trimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yloxy]-hexadecanoic acid methyl ester
There total 12 articles about 11-[7-(3,4-diacetoxy-5-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,2,6-trimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yloxy]-hexadecanoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trimethylsilyl trifluoromethanesulfonate;
In
dichloromethane;
at -78 - 20 ℃;
DOI:10.1055/s-2006-956493
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 95 percent / pyridine / 20 °C
2: 85 percent / H2 / Pd/C / ethanol / 60 °C
3: 67 percent / Jones reagent / acetone / 20 °C
4: 85 percent / boron trifluoride-diethyl ether / 40 °C
5: 66 percent / boron trifluoride-diethyl ether / CH2Cl2 / -78 - 20 °C
6: NaOMe / methanol / -20 °C
7: p-TsOH / dimethylformamide / 20 °C
8: 96 percent / trimethylsilyl trifluoromethanesulfonate / CH2Cl2 / -78 - 20 °C
With
jones reagent; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; hydrogen; sodium methylate; toluene-4-sulfonic acid;
palladium on activated charcoal;
In
pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
3: Jones oxidation;
DOI:10.1055/s-2006-956493
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 85 percent / H2 / Pd/C / ethanol / 60 °C
2: 67 percent / Jones reagent / acetone / 20 °C
3: 85 percent / boron trifluoride-diethyl ether / 40 °C
4: 66 percent / boron trifluoride-diethyl ether / CH2Cl2 / -78 - 20 °C
5: NaOMe / methanol / -20 °C
6: p-TsOH / dimethylformamide / 20 °C
7: 96 percent / trimethylsilyl trifluoromethanesulfonate / CH2Cl2 / -78 - 20 °C
With
jones reagent; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; hydrogen; sodium methylate; toluene-4-sulfonic acid;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
2: Jones oxidation;
DOI:10.1055/s-2006-956493
