C₁₈H₂₇NO

Base Information

Chemical Name:C₁₈H₂₇NO
CAS No.:1613157-85-9
Molecular Formula:C₁₈H₂₇NO
Molecular Weight:273.418
Hs Code.:

Synonyms:C₁₈H₂₇NO

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Chemical Property of C₁₈H₂₇NO

Chemical Property:

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Technology Process of C₁₈H₂₇NO

There total 8 articles about C₁₈H₂₇NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 10531-16-5
p-butylbenzylbromide

: 1613157-83-7
(1R,3S,5S)-3-methyl-8-oxa-6-azabicyclo[3.2.1]octane hydrochloride

: 1613157-85-9
C₁₈H₂₇NO

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.040

Reference yield:

: 710336-74-6
tert-butyl (R)-5-[(S)-3-hydroxy-2-methylpropyl]-2,2-dimethyloxazolidine-3-carboxylate

: 1613157-85-9
C₁₈H₂₇NO

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide; dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 2 h / 0 °C / Inert atmosphere

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 1 h / 0 - 20 °C

4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 20 °C / Molecular sieve; Inert atmosphere

5.1: acetic acid / water / 18 h / 60 °C

6.1: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C / Inert atmosphere

7.1: triethylamine / acetonitrile / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; tetrapropylammonium perruthennate; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; acetic acid; 4-methylmorpholine N-oxide; triethylamine; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetonitrile; 2.1: |Wittig Olefination / 2.2: |Wittig Olefination;
DOI:10.1016/j.bmc.2014.04.040

Reference yield:

: 1613157-79-1
tert-butyl (R)-2,2-dimethyl-5-((S)-2-methylbut-3-en-1-yl)oxazolidine-3-carboxylate

: 1613157-85-9
C₁₈H₂₇NO

Guidance literature:: Multi-step reaction with 5 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C

2.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 20 °C / Molecular sieve; Inert atmosphere

3.1: acetic acid / water / 18 h / 60 °C

4.1: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C / Inert atmosphere

5.1: triethylamine / acetonitrile / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; tetrapropylammonium perruthennate; acetic acid; 4-methylmorpholine N-oxide; triethylamine; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmc.2014.04.040