3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(1-phenyl-ethyl)-succinamic acid

Base Information

Chemical Name:3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(1-phenyl-ethyl)-succinamic acid
CAS No.:512785-29-4
Molecular Formula:C₃₂H₃₁N₃O₆
Molecular Weight:553.615
Hs Code.:

3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-<i>N</i>-(1-phenyl-ethyl)-succinamic acid

Synonyms:3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(1-phenyl-ethyl)-succinamic acid

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Chemical Property of 3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(1-phenyl-ethyl)-succinamic acid

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Technology Process of 3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(1-phenyl-ethyl)-succinamic acid

There total 7 articles about 3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(1-phenyl-ethyl)-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 512785-21-6
3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(1-phenyl-ethyl)-succinamic acid tert-butyl ester

: 512785-29-4
3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(1-phenyl-ethyl)-succinamic acid

Guidance literature:: With formic acid; at 20 ℃;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: 512785-11-4
N-[(benzyloxy)carbonyl]-D-aspartic acid β-tert-butyl ester α-[(R)-α-methylbenzyl]amide

: 512785-29-4
3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(1-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / hydrogen / palladium on carbon / methanol

2: magnesium sulfate / CH₂Cl₂ / 20 °C

3: 0.25 g / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

4: 100 percent / formic acid / 20 °C

With formic acid; hydrogen; magnesium sulfate; palladium on activated charcoal; In methanol; dichloromethane; 3: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 512785-29-4
3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(1-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; HOAt / CH₂Cl₂ / 20 °C

2: 100 percent / hydrogen / palladium on carbon / methanol

3: magnesium sulfate / CH₂Cl₂ / 20 °C

4: 0.25 g / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

5: 100 percent / formic acid / 20 °C

With formic acid; 1-hydroxy-7-aza-benzotriazole; hydrogen; magnesium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; 4: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031