[6-(4-Carboxymethoxy-benzyl)-8-carboxymethyl-3,3,10,10-tetramethyl-[1,2,5,8]dithiadiazecan-5-yl]-acetic acid

Base Information

• Chemical Name: [6-(4-Carboxymethoxy-benzyl)-8-carboxymethyl-3,3,10,10-tetramethyl-[1,2,5,8]dithiadiazecan-5-yl]-acetic acid
• CAS No.: 207386-72-9
• Molecular Formula: C₂₃H₃₄N₂O₇S₂
• Molecular Weight: 514.664
• Mol file: 207386-72-9.mol

Synonyms:[6-(4-Carboxymethoxy-benzyl)-8-carboxymethyl-3,3,10,10-tetramethyl-[1,2,5,8]dithiadiazecan-5-yl]-acetic acid

Chemical Property of [6-(4-Carboxymethoxy-benzyl)-8-carboxymethyl-3,3,10,10-tetramethyl-[1,2,5,8]dithiadiazecan-5-yl]-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [6-(4-Carboxymethoxy-benzyl)-8-carboxymethyl-3,3,10,10-tetramethyl-[1,2,5,8]dithiadiazecan-5-yl]-acetic acid

There total 3 articles about [6-(4-Carboxymethoxy-benzyl)-8-carboxymethyl-3,3,10,10-tetramethyl-[1,2,5,8]dithiadiazecan-5-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

[6-(4-tert-Butoxycarbonylmethoxy-benzyl)-8-tert-butoxycarbonylmethyl-3,3,10,10-tetramethyl-[1,2,5,8]dithiadiazecan-5-yl]-acetic acid tert-butyl ester (207386-71-8) → [6-(4-Carboxymethoxy-benzyl)-8-carboxymethyl-3,3,10,10-tetramethyl-[1,2,5,8]dithiadiazecan-5-yl]-acetic acid (207386-72-9)

Guidance literature:

With trifluoroacetic acid; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(98)00121-5

Reference yield:

2,2'-dithiobis(2-methylpropanal) (15581-80-3) → [6-(4-Carboxymethoxy-benzyl)-8-carboxymethyl-3,3,10,10-tetramethyl-[1,2,5,8]dithiadiazecan-5-yl]-acetic acid (207386-72-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / NaBH₃CN / methanol / 3 h / Ambient temperature

2: 75 percent / K₂CO₃, KI / acetonitrile / 22 h / Ambient temperature

3: 81 percent / CF₃COOH / 24 h / Ambient temperature

With sodium cyanoborohydride; potassium carbonate; trifluoroacetic acid; potassium iodide; In methanol; acetonitrile;

DOI:10.1016/S0040-4020(98)00121-5

Reference yield:

6-(4-hydroxybenzyl)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazacyclodecane (207386-70-7) → [6-(4-Carboxymethoxy-benzyl)-8-carboxymethyl-3,3,10,10-tetramethyl-[1,2,5,8]dithiadiazecan-5-yl]-acetic acid (207386-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / K₂CO₃, KI / acetonitrile / 22 h / Ambient temperature

2: 81 percent / CF₃COOH / 24 h / Ambient temperature

With potassium carbonate; trifluoroacetic acid; potassium iodide; In acetonitrile;

DOI:10.1016/S0040-4020(98)00121-5

upstream raw materials:

[6-(4-tert-Butoxycarbonylmethoxy-benzyl)-8-tert-butoxycarbonylmethyl-3,3,10,10-tetramethyl-[1,2,5,8]dithiadiazecan-5-yl]-acetic acid tert-butyl ester

2,2'-dithiobis(2-methylpropanal)

6-(4-hydroxybenzyl)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazacyclodecane