(S)-(1-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-piperidin-3-yl)-acetic acid

Base Information

Chemical Name:(S)-(1-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-piperidin-3-yl)-acetic acid
CAS No.:1334404-24-8
Molecular Formula:C₂₁H₂₅F₃N₄O₄
Molecular Weight:454.449
Hs Code.:

Synonyms:(S)-(1-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-piperidin-3-yl)-acetic acid

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Chemical Property of (S)-(1-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-piperidin-3-yl)-acetic acid

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Technology Process of (S)-(1-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-piperidin-3-yl)-acetic acid

There total 5 articles about (S)-(1-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-piperidin-3-yl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39931-77-6
pyridin-3-yl-acetic acid ethyl ester

: 1334404-24-8
(S)-(1-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-piperidin-3-yl)-acetic acid

: 1334404-25-9
(R)-(1-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-piperidin-3-yl)-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; L-Tartaric acid; Adam’s catalyst / ethanol / 5 h / 20 °C / 2585.81 Torr

1.2: pH 11 - 12

2.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 17 h / 140 °C

3.1: water; lithium hydroxide monohydrate / methanol / 17 h / 20 °C

3.2: pH 5

4.1: Chiralpak AD / isopropyl alcohol; formic acid; methanol / Resolution of racemate

With Adam’s catalyst; lithium hydroxide monohydrate; L-Tartaric acid; water; hydrogen; potassium carbonate; In 1-methyl-pyrrolidin-2-one; methanol; formic acid; ethanol; isopropyl alcohol;

Reference yield:

: 64995-88-6,81290-45-1
ethyl 2-(piperidin-3-yl)acetate

: 1334404-24-8
(S)-(1-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-piperidin-3-yl)-acetic acid

: 1334404-25-9
(R)-(1-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-piperidin-3-yl)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 17 h / 140 °C

2.1: water; lithium hydroxide monohydrate / methanol / 17 h / 20 °C

2.2: pH 5

3.1: Chiralpak AD / isopropyl alcohol; formic acid; methanol / Resolution of racemate

With lithium hydroxide monohydrate; water; potassium carbonate; In 1-methyl-pyrrolidin-2-one; methanol; formic acid; isopropyl alcohol;

Reference yield:

: 2-(4-trifluoromethoxy-phenyl)-ethylamine hydrochloride

: 1334404-24-8
(S)-(1-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-piperidin-3-yl)-acetic acid

: 1334404-25-9
(R)-(1-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-piperidin-3-yl)-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / ethanol / 17 h / 90 °C

2.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 17 h / 140 °C

3.1: water; lithium hydroxide monohydrate / methanol / 17 h / 20 °C

3.2: pH 5

4.1: Chiralpak AD / isopropyl alcohol; formic acid; methanol / Resolution of racemate

With lithium hydroxide monohydrate; water; sodium hydrogencarbonate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; methanol; formic acid; ethanol; isopropyl alcohol;