Technology Process of (R,R)-(+)-N-<(1phenyl)ethyl>-3-methyl-4,4,4-trichlorobutanamide
There total 10 articles about (R,R)-(+)-N-<(1phenyl)ethyl>-3-methyl-4,4,4-trichlorobutanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 63 percent / pyridinium chlorochromate / CH2Cl2 / 3 h / Ambient temperature
2: 1.) tert-butylamine, CCl4; 2.) N-chlorosuccinimide
3: 76 percent / potassium permanganate / H2O / 0.33 h / 65 °C
4: 1.) Pb(OAc)4; 2.) LiCl / 1.) benzene; 2.) benzene, 80-85 deg C
5: 68 percent / 1.48 M DIBAL / toluene / 1 h
6: 85 percent / Jones reagent / acetone / 0.17 h
7: 1.) thionyl chloride / 1.) benzene, 1 h, reflux; 2.) benzene, ether, 20 min
With
lead(IV) acetate; tetrachloromethane; potassium permanganate; N-chloro-succinimide; thionyl chloride; jones reagent; diisobutylaluminium hydride; tert-butylamine; pyridinium chlorochromate; lithium chloride;
In
dichloromethane; water; acetone; toluene;
DOI:10.1021/ja00287a036
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 85 percent / Jones reagent / acetone / 0.17 h
2: 1.) thionyl chloride / 1.) benzene, 1 h, reflux; 2.) benzene, ether, 20 min
With
thionyl chloride; jones reagent;
In
acetone;
DOI:10.1021/ja00287a036
