[5,7-Dichloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester

Base Information

Chemical Name:[5,7-Dichloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester
CAS No.:72482-19-0
Molecular Formula:C₁₇H₁₂Cl₂FNO₄
Molecular Weight:384.191
Hs Code.:

Synonyms:[5,7-Dichloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester

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Chemical Property of [5,7-Dichloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester

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Technology Process of [5,7-Dichloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester

There total 9 articles about [5,7-Dichloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7051-15-2
2-chlororesorcinol dimethyl ether

: 72482-19-0
[5,7-Dichloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 67 percent / AlCl₃ / 1,2-dichloro-ethane / 1.) from 5 deg C to RT, 30 min, 2.) reflux, 30 min

2: 76 percent / hydroxylamine hydrochloride, pyridine / 24 h / Heating

3: 98 percent / 1 h / Heating

4: 84 percent / sodium hydride / dimethylformamide / 0.67 h / 30 °C

5: 95 percent / gaseous Cl₂ / acetic acid / Ambient temperature

6: pyridine hydrochloride / 2 h / 180 °C

7: K₂CO₃ / dimethylformamide / 1.) 60 deg C, 2 h, 2.) from 60 deg C to RT, overnight

With pyridine; aluminium trichloride; hydroxylamine hydrochloride; pyridine hydrochloride; chlorine; sodium hydride; potassium carbonate; In acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008

Reference yield:

: 72482-07-6
3-chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone

: 72482-19-0
[5,7-Dichloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / hydroxylamine hydrochloride, pyridine / 24 h / Heating

2: 98 percent / 1 h / Heating

3: 84 percent / sodium hydride / dimethylformamide / 0.67 h / 30 °C

4: 95 percent / gaseous Cl₂ / acetic acid / Ambient temperature

5: pyridine hydrochloride / 2 h / 180 °C

6: K₂CO₃ / dimethylformamide / 1.) 60 deg C, 2 h, 2.) from 60 deg C to RT, overnight

With pyridine; hydroxylamine hydrochloride; pyridine hydrochloride; chlorine; sodium hydride; potassium carbonate; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008

Reference yield:

: 72482-05-4
7-chloro-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole

: 72482-19-0
[5,7-Dichloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / gaseous Cl₂ / acetic acid / Ambient temperature

2: pyridine hydrochloride / 2 h / 180 °C

3: K₂CO₃ / dimethylformamide / 1.) 60 deg C, 2 h, 2.) from 60 deg C to RT, overnight

With pyridine hydrochloride; chlorine; potassium carbonate; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008