(S)-3-[4-(Diethoxy-phosphoryl)-benzyl]-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester

Base Information

Chemical Name:(S)-3-[4-(Diethoxy-phosphoryl)-benzyl]-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester
CAS No.:429687-06-9
Molecular Formula:C₂₉H₃₈NO₈P
Molecular Weight:559.596
Hs Code.:

Synonyms:(S)-3-[4-(Diethoxy-phosphoryl)-benzyl]-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester

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Chemical Property of (S)-3-[4-(Diethoxy-phosphoryl)-benzyl]-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester

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Technology Process of (S)-3-[4-(Diethoxy-phosphoryl)-benzyl]-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester

There total 7 articles about (S)-3-[4-(Diethoxy-phosphoryl)-benzyl]-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 429687-05-8
{4-[3-((4R,5S)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl]-phenyl}-phosphonic acid diethyl ester

: 429687-06-9
(S)-3-[4-(Diethoxy-phosphoryl)-benzyl]-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester

: (R)-3-[4-(Diethoxy-phosphoryl)-benzyl]-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1016/S0040-4039(02)00004-7

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 429687-06-9
(S)-3-[4-(Diethoxy-phosphoryl)-benzyl]-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 63 percent / NaH / tetrahydrofuran

2.1: 81 percent / Pd(PPh₃)4

3.1: TFA / CH₂Cl₂

3.2: 84 percent / toluene / Heating

4.1: N-methylmorpholine / tetrahydrofuran

5.1: 53 percent / n-BuLi / tetrahydrofuran

6.1: 63 percent / NaHMDS / tetrahydrofuran / 2 h / -78 °C

With 4-methyl-morpholine; n-butyllithium; sodium hexamethyldisilazane; sodium hydride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(02)00004-7

Reference yield:

: 429687-12-7
2-(4-bromo-benzyl)-malonic acid di-tert-butyl ester

: 429687-06-9
(S)-3-[4-(Diethoxy-phosphoryl)-benzyl]-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 81 percent / Pd(PPh₃)4

2.1: TFA / CH₂Cl₂

2.2: 84 percent / toluene / Heating

3.1: N-methylmorpholine / tetrahydrofuran

4.1: 53 percent / n-BuLi / tetrahydrofuran

5.1: 63 percent / NaHMDS / tetrahydrofuran / 2 h / -78 °C

With 4-methyl-morpholine; n-butyllithium; sodium hexamethyldisilazane; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(02)00004-7