ethyl 3-[2-fluoro-5-(trifluoromethyl)phenyl]-3-oxopropanoate

Base Information

• Chemical Name: ethyl 3-[2-fluoro-5-(trifluoromethyl)phenyl]-3-oxopropanoate
• CAS No.: 870823-14-6
• Molecular Formula: C₁₂H₁₀F₄O₃
• Molecular Weight: 278.203
• Mol file: 870823-14-6.mol

Synonyms:ethyl 3-[2-fluoro-5-(trifluoromethyl)phenyl]-3-oxopropanoate

Chemical Property of ethyl 3-[2-fluoro-5-(trifluoromethyl)phenyl]-3-oxopropanoate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 3-[2-fluoro-5-(trifluoromethyl)phenyl]-3-oxopropanoate

There total 1 articles about ethyl 3-[2-fluoro-5-(trifluoromethyl)phenyl]-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-5-(trifluoromethyl)benzoyl chloride (207981-46-2) → ethyl 3-[2-fluoro-5-(trifluoromethyl)phenyl]-3-oxopropanoate (870823-14-6)

Guidance literature:

ethyl potassium malonate; With triethylamine; magnesium chloride; In ethyl acetate; at 40 ℃; for 15h;

2-fluoro-5-(trifluoromethyl)benzoyl chloride; In ethyl acetate; for 2h;

Reference yield:

ethyl 3-[2-fluoro-5-(trifluoromethyl)phenyl]-3-oxopropanoate (870823-14-6) + {(1S)-1-[4-(ethoxycarbonyl)phenyl]ethyl}hydrazinium trifluoroacetate (870822-92-7) → ethyl 4-((1S)-1-{3-[2-fluoro-5-(trifluoromethyl)phenyl]-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}ethyl)benzoate (870823-15-7)

Guidance literature:

In acetonitrile; at 85 ℃; for 8h;

upstream raw materials:

2-fluoro-5-(trifluoromethyl)benzoyl chloride

Downstream raw materials:

ethyl 4-((1S)-1-{3-[2-fluoro-5-(trifluoromethyl)phenyl]-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}ethyl)benzoate