6-(3,4-dimethoxy-phenyl)-3-(2-imidazol-1-yl-pyrimidin-4-yl)-2-methyl-imidazo[1,2-b]pyridazine

Base Information

Chemical Name:6-(3,4-dimethoxy-phenyl)-3-(2-imidazol-1-yl-pyrimidin-4-yl)-2-methyl-imidazo[1,2-b]pyridazine
CAS No.:1083429-49-5
Molecular Formula:C₂₂H₁₉N₇O₂
Molecular Weight:413.439
Hs Code.:

Synonyms:6-(3,4-dimethoxy-phenyl)-3-(2-imidazol-1-yl-pyrimidin-4-yl)-2-methyl-imidazo[1,2-b]pyridazine

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Chemical Property of 6-(3,4-dimethoxy-phenyl)-3-(2-imidazol-1-yl-pyrimidin-4-yl)-2-methyl-imidazo[1,2-b]pyridazine

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Technology Process of 6-(3,4-dimethoxy-phenyl)-3-(2-imidazol-1-yl-pyrimidin-4-yl)-2-methyl-imidazo[1,2-b]pyridazine

There total 7 articles about 6-(3,4-dimethoxy-phenyl)-3-(2-imidazol-1-yl-pyrimidin-4-yl)-2-methyl-imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-32-4
1H-imidazole

: 1083429-97-3
6-(3,4-dimethoxy-phenyl)-3-(2-methanesulfinyl-pyrimidin-4-yl)-2-methyl-imidazo[1,2-b]pyridazine

: 1083429-49-5
6-(3,4-dimethoxy-phenyl)-3-(2-imidazol-1-yl-pyrimidin-4-yl)-2-methyl-imidazo[1,2-b]pyridazine

Guidance literature:: In 1,4-dioxane; at 75 - 170 ℃; for 10.5h; Microwave irradiation;

Reference yield:

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 1083429-49-5
6-(3,4-dimethoxy-phenyl)-3-(2-imidazol-1-yl-pyrimidin-4-yl)-2-methyl-imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 20 h / 105 °C

2: triethylamine / ISOPROPYLAMIDE / 170 °C / Microwave irradiation

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 0 °C

4: 1,4-dioxane / 10.5 h / 75 - 170 °C / Microwave irradiation

With potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;

Reference yield:

: 1083429-95-1
1-chloro-1-(2-methylsulfanyl-pyrimidin-4-yl)-propan-2-one

: 1083429-49-5
6-(3,4-dimethoxy-phenyl)-3-(2-imidazol-1-yl-pyrimidin-4-yl)-2-methyl-imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ISOPROPYLAMIDE / 170 °C / Microwave irradiation

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 0 °C

3: 1,4-dioxane / 10.5 h / 75 - 170 °C / Microwave irradiation

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; ISOPROPYLAMIDE;