(2S,3S,4R,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-3,4-dihydroxytetrahydrofuran

Base Information

• Chemical Name: (2S,3S,4R,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-3,4-dihydroxytetrahydrofuran
• CAS No.: 233679-17-9
• Molecular Formula: C₄₇H₄₃NO₁₅S
• Molecular Weight: 893.922

Synonyms:(2S,3S,4R,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-3,4-dihydroxytetrahydrofuran

Chemical Property of (2S,3S,4R,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-3,4-dihydroxytetrahydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S,4R,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-3,4-dihydroxytetrahydrofuran

There total 9 articles about (2S,3S,4R,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-3,4-dihydroxytetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2S,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-2,5-dihydrofuran (233679-10-2) → (2S,3S,4R,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-3,4-dihydroxytetrahydrofuran (233679-17-9)

Guidance literature:

With monopotassium phosphate buffer; 4-methylmorpholine N-oxide; osmium(VIII) oxide; In dichloromethane; water; at 20 ℃; for 24h;

DOI:10.1021/jo990195x

Reference yield:

sodium benzenesulfonate (873-55-2) → (2S,3S,4R,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-3,4-dihydroxytetrahydrofuran (233679-17-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / monopotassium phosphate buffer / H₂O / 1 h / 20 °C

2: 61 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / -78 - 0 °C

3: 84 percent / sodium hydride; 1,3-bis(diphenylphosphino)propane / bis(η³-allyl)di-μ-chlorodipalladium / tetrahydrofuran / 3 h / 0 °C / sonication

4: 89 percent / N-methylmorpholine N-oxide; monopotassium phosphate buffer / osmium tetraoxide / CH₂Cl₂; H₂O / 24 h / 20 °C

With di-isopropyl azodicarboxylate; monopotassium phosphate buffer; 1,3-bis-(diphenylphosphino)propane; sodium hydride; 4-methylmorpholine N-oxide; triphenylphosphine; osmium(VIII) oxide; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; dichloromethane; water; 1: Michael addition / 2: Alkylation / 3: Alkylation / 4: Oxidation;

DOI:10.1021/jo990195x

Reference yield:

thiophenol (108-98-5) → (2S,3S,4R,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-3,4-dihydroxytetrahydrofuran (233679-17-9)

Guidance literature:

Multi-step reaction with 5 steps

2: hydrogen peroxide / acetic acid

3: 61 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / -78 - 0 °C

4: 84 percent / sodium hydride; 1,3-bis(diphenylphosphino)propane / bis(η³-allyl)di-μ-chlorodipalladium / tetrahydrofuran / 3 h / 0 °C / sonication

5: 89 percent / N-methylmorpholine N-oxide; monopotassium phosphate buffer / osmium tetraoxide / CH₂Cl₂; H₂O / 24 h / 20 °C

With di-isopropyl azodicarboxylate; monopotassium phosphate buffer; 1,3-bis-(diphenylphosphino)propane; dihydrogen peroxide; sodium hydride; 4-methylmorpholine N-oxide; triphenylphosphine; osmium(VIII) oxide; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; dichloromethane; water; acetic acid; 1: Addition / 2: Oxidation / 3: Alkylation / 4: Alkylation / 5: Oxidation;

DOI:10.1021/jo990195x

upstream raw materials:

(2S,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-2,5-dihydrofuran

sodium benzenesulfonate

thiophenol

3-(phenylthio)-2,5-pyrrolidinedione

Downstream raw materials:

(2S,3S,4R,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-3,4-dihydroxytetrahydrofuran acetonide

2-{(3aR,4R,6S,6aS)-6-[3-Benzenesulfonyl-1-(4-methoxy-benzyl)-2,5-dioxo-pyrrolidin-3-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2-hydroxy-malonic acid

(3aR,4R,6S,6aS)-6-[3-Benzenesulfonyl-1-(4-methoxy-benzyl)-2,5-dioxo-pyrrolidin-3-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid

(2S,3S,4S,5S)-5-hydroxymethyl-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-3,4-dihydroxytetrahydrofuran acetonide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 233679-17-9 (2S,3S,4R,5R)-5-[di(benzyloxycarbonyl)(benzyloxycarbonyloxy)methyl]-2-[3'-phenylsulfonyl-N'-(4-methoxybenzyl)succinimid-3'-yl]-3,4-dihydroxytetrahydrofuran

Send

Send

Metric Ton KG G Pound L ML

Send

Send