(S)-2-{(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-2-methyl-pentanoylamino)-2-methyl-pentanoylamino]-2-methyl-pentanoylamino}-2-methyl-pentanoic acid

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Chemical Name:(S)-2-{(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-2-methyl-pentanoylamino)-2-methyl-pentanoylamino]-2-methyl-pentanoylamino}-2-methyl-pentanoic acid
CAS No.:616241-41-9
Molecular Formula:C₃₂H₅₂N₄O₇
Molecular Weight:604.787
Hs Code.:

(S)-2-{(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-2-methyl-pentanoylamino)-2-methyl-pentanoylamino]-2-methyl-pentanoylamino}-2-methyl-pentanoic acid

Synonyms:(S)-2-{(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-2-methyl-pentanoylamino)-2-methyl-pentanoylamino]-2-methyl-pentanoylamino}-2-methyl-pentanoic acid

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Chemical Property of (S)-2-{(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-2-methyl-pentanoylamino)-2-methyl-pentanoylamino]-2-methyl-pentanoylamino}-2-methyl-pentanoic acid

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Technology Process of (S)-2-{(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-2-methyl-pentanoylamino)-2-methyl-pentanoylamino]-2-methyl-pentanoylamino}-2-methyl-pentanoic acid

There total 8 articles about (S)-2-{(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-2-methyl-pentanoylamino)-2-methyl-pentanoylamino]-2-methyl-pentanoylamino}-2-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 616241-34-0
Z-[L-(αMe)Nva]4-OtBu

: 616241-41-9
(S)-2-{(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-2-methyl-pentanoylamino)-2-methyl-pentanoylamino]-2-methyl-pentanoylamino}-2-methyl-pentanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ma030327v

Reference yield:

: 616241-30-6
Z-[L-(αMe)Nva]2-OtBu

: 616241-41-9
(S)-2-{(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-2-methyl-pentanoylamino)-2-methyl-pentanoylamino]-2-methyl-pentanoylamino}-2-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 9.60 g / H₂ / CH₂Cl₂

2: 57 percent / 7-aza-1-hydroxy-1,2,3-benzotriazole; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; N-methylmorpholine / CH₂Cl₂ / 144 h / 20 °C

3: 5.97 g / H₂ / CH₂Cl₂

4: 73 percent / 7-aza-1-hydroxy-1,2,3-benzotriazole; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; N-methylmorpholine / CH₂Cl₂ / 144 h / 20 °C

5: 0.09 g / trifluoroacetic acid / CH₂Cl₂

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ma030327v

Reference yield:

: 616241-33-9
H-[L-(αMe)Nva]2-OtBu

: 616241-41-9
(S)-2-{(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-2-methyl-pentanoylamino)-2-methyl-pentanoylamino]-2-methyl-pentanoylamino}-2-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / 7-aza-1-hydroxy-1,2,3-benzotriazole; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; N-methylmorpholine / CH₂Cl₂ / 144 h / 20 °C

2: 5.97 g / H₂ / CH₂Cl₂

3: 73 percent / 7-aza-1-hydroxy-1,2,3-benzotriazole; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; N-methylmorpholine / CH₂Cl₂ / 144 h / 20 °C

4: 0.09 g / trifluoroacetic acid / CH₂Cl₂

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ma030327v