((1S,4S)-4-Bromomethyl-2,2-dimethyl-3-methylene-cyclohexyl)-methanol

Base Information

• Chemical Name: ((1S,4S)-4-Bromomethyl-2,2-dimethyl-3-methylene-cyclohexyl)-methanol
• CAS No.: 91309-39-6
• Molecular Formula: C₁₁H₁₉BrO
• Molecular Weight: 247.175
• Mol file: 91309-39-6.mol

Synonyms:((1S,4S)-4-Bromomethyl-2,2-dimethyl-3-methylene-cyclohexyl)-methanol

Chemical Property of ((1S,4S)-4-Bromomethyl-2,2-dimethyl-3-methylene-cyclohexyl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1S,4S)-4-Bromomethyl-2,2-dimethyl-3-methylene-cyclohexyl)-methanol

There total 1 articles about ((1S,4S)-4-Bromomethyl-2,2-dimethyl-3-methylene-cyclohexyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid (1S,4S)-4-bromomethyl-2,2-dimethyl-3-methylene-cyclohexylmethyl ester (73616-73-6,76231-57-7) → ((1S,4S)-4-Bromomethyl-2,2-dimethyl-3-methylene-cyclohexyl)-methanol (91309-39-6)

Guidance literature:

With potassium hydroxide; In methanol; for 1.5h; Ambient temperature;

DOI:10.1248/cpb.32.1294

Reference yield: 97.0%

((1S,4S)-4-Bromomethyl-2,2-dimethyl-3-methylene-cyclohexyl)-methanol (91309-39-6) + ethyl vinyl ether (109-92-2,25104-37-4) → (3S,6S)-3-Bromomethyl-6-(2-ethoxy-ethoxymethyl)-1,1-dimethyl-2-methylene-cyclohexane

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 0.5h;

DOI:10.1248/cpb.32.1294

Reference yield:

((1S,4S)-4-Bromomethyl-2,2-dimethyl-3-methylene-cyclohexyl)-methanol (91309-39-6) → Acetic acid (3S,5R)-3-methoxy-5-(1-methoxy-1-methyl-ethoxymethyl)-2,6,6-trimethyl-cyclohex-1-enylmethyl ester (91318-85-3)

Guidance literature:

Multi-step reaction with 13 steps

1: 97 percent / p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 0.5 h

2: 42 percent / 80 percent m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / Ambient temperature

3: 82 percent / sodium tertiary amylate / tetrahydrofuran; dimethylsulfoxide / 0.05 h / 70 °C

4: 92 percent / Na, liq. NH₃ / tetrahydrofuran / 0.5 h / -78 °C

5: 635 mg / pyridine / Ambient temperature

6: 92 percent / selenium dioxide / dioxane; pyridine / 2.5 h / 80 °C

7: 95 percent / silver oxide / dimethylformamide / 24 h / Ambient temperature

8: 96 percent / p-toluenesulfonic acid monohydrate / aq. ethanol / 1.5 h / Ambient temperature

9: 100 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

10: 28 percent / 10 percent NaOMe / methanol / 0.5 h / Ambient temperature

11: 83 mg / pyridine / 2 h / Ambient temperature

12: 98 percent / sodium borohydride / methanol / 0.08 h

13: 184 mg / 1) phosphorus oxychloride; 2) Et₃N / 0.17 h / Ambient temperature

With sodium tetrahydroborate; selenium(IV) oxide; ammonia; sodium methylate; sodium; sodium tert-pentoxide; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; silver(l) oxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1248/cpb.32.1294

upstream raw materials:

Acetic acid (1S,4S)-4-bromomethyl-2,2-dimethyl-3-methylene-cyclohexylmethyl ester

Downstream raw materials:

((1R,5S)-3-Chloromethyl-5-methoxy-2,2,4-trimethyl-cyclohex-3-enyl)-methanol

2-((1R,5S)-3-Chloromethyl-5-methoxy-2,2,4-trimethyl-cyclohex-3-enyl)-ethanol

(4R,6S)-2-Chloromethyl-6-methoxy-4-(1-methoxy-1-methyl-ethoxymethyl)-1,3,3-trimethyl-cyclohexene

[(3S,5R)-3-Methoxy-5-(1-methoxy-1-methyl-ethoxymethyl)-2,6,6-trimethyl-cyclohex-1-enyl]-methanol