3-((tert-butyldiphenylsilyloxy)methyl)-4-hydroxy-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclopent-2-enone

Base Information

Chemical Name:3-((tert-butyldiphenylsilyloxy)methyl)-4-hydroxy-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclopent-2-enone
CAS No.:1384870-78-3
Molecular Formula:C₂₈H₃₆O₅Si
Molecular Weight:480.676
Hs Code.:

Synonyms:3-((tert-butyldiphenylsilyloxy)methyl)-4-hydroxy-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclopent-2-enone

Suppliers and Price of 3-((tert-butyldiphenylsilyloxy)methyl)-4-hydroxy-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclopent-2-enone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-((tert-butyldiphenylsilyloxy)methyl)-4-hydroxy-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclopent-2-enone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-((tert-butyldiphenylsilyloxy)methyl)-4-hydroxy-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclopent-2-enone

There total 7 articles about 3-((tert-butyldiphenylsilyloxy)methyl)-4-hydroxy-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclopent-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 5-((tert-butyldiphenylsilyloxy)methyl)-1-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclopent-4-ene-1,3-diol

: 1384870-78-3
3-((tert-butyldiphenylsilyloxy)methyl)-4-hydroxy-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclopent-2-enone

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol301513h

Reference yield:

: 5554-99-4
(2-methylfuran-3-yl)methanol

: 1384870-78-3
3-((tert-butyldiphenylsilyloxy)methyl)-4-hydroxy-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclopent-2-enone

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / diethyl ether / 3 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: hydroquinone / 3.5 h / pH 6.3 / aq. phosphate buffer; Reflux

3.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: tert.-butyl lithium / diethyl ether; pentane / 1.75 h / -78 - 20 °C / Inert atmosphere

4.2: 2 h / -78 - 20 °C / Inert atmosphere

5.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

With 1H-imidazole; dmap; bromine; tert.-butyl lithium; sodium hydrogencarbonate; Dess-Martin periodane; hydroquinone; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.1021/ol301513h

Reference yield:

: 76374-24-8,76374-33-9,90371-07-6
2,5-dihydro-3-hydroxymethyl-2,5-dimethoxy-2-methylfuran

: 1384870-78-3
3-((tert-butyldiphenylsilyloxy)methyl)-4-hydroxy-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclopent-2-enone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroquinone / 3.5 h / pH 6.3 / aq. phosphate buffer; Reflux

2.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: tert.-butyl lithium / diethyl ether; pentane / 1.75 h / -78 - 20 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

With 1H-imidazole; dmap; tert.-butyl lithium; sodium hydrogencarbonate; Dess-Martin periodane; hydroquinone; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.1021/ol301513h