2-bromomethyl-4-(4-methoxy-phenyl)-5-(4-trifluoromethyl-phenyl)-thiazole

Base Information

• Chemical Name: 2-bromomethyl-4-(4-methoxy-phenyl)-5-(4-trifluoromethyl-phenyl)-thiazole
• CAS No.: 870521-06-5
• Molecular Formula: C₁₈H₁₃BrF₃NOS
• Molecular Weight: 428.273

Synonyms:2-bromomethyl-4-(4-methoxy-phenyl)-5-(4-trifluoromethyl-phenyl)-thiazole

Chemical Property of 2-bromomethyl-4-(4-methoxy-phenyl)-5-(4-trifluoromethyl-phenyl)-thiazole

Chemical Property:

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Technology Process of 2-bromomethyl-4-(4-methoxy-phenyl)-5-(4-trifluoromethyl-phenyl)-thiazole

There total 1 articles about 2-bromomethyl-4-(4-methoxy-phenyl)-5-(4-trifluoromethyl-phenyl)-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-(4-methoxyphenyl)-2-methyl-5-(4-trifluoromethylphenyl)thiazole (870521-08-7) → 2-bromomethyl-4-(4-methoxy-phenyl)-5-(4-trifluoromethyl-phenyl)-thiazole (870521-06-5)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 60 ℃; for 16h;

DOI:10.1021/jm9007399

Reference yield:

2-bromomethyl-4-(4-methoxy-phenyl)-5-(4-trifluoromethyl-phenyl)-thiazole (870521-06-5) + (RS)-methyl 2-(4-hydroxyphenoxy)propionate (60075-04-9) → 2-{4-[4-(4-methoxy-phenyl)-5-(4-trifluoromethyl-phenyl)-thiazol-2-ylmethoxy]-phenoxy}-propionic acid methyl ester

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

2-bromomethyl-4-(4-methoxy-phenyl)-5-(4-trifluoromethyl-phenyl)-thiazole (870521-06-5) + methyl 2-(4-hydroxyphenoxy)acetate (70067-75-3) → C27H22F3NO5S

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1021/jm9007399

upstream raw materials:

4-(4-methoxyphenyl)-2-methyl-5-(4-trifluoromethylphenyl)thiazole

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