Technology Process of 15-benzyloxy-pentadec-2-yn-1-ol
There total 1 articles about 15-benzyloxy-pentadec-2-yn-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
propargyl alcohol;
With
lithium amide;
In
tetrahydrofuran; ammonia;
at -45 ℃;
for 1.5h;
benzyl-(12-bromododecyl)-ether;
In
tetrahydrofuran; ammonia;
at -45 ℃;
for 1h;
DOI:10.1021/jo049505o
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 82 percent / NaBH4; ethylene-diamine; hydrogen / Ni(OAc)2*4H2O / methanol / 5 h / 20 °C
2.1: (+)-diethyl tartrate; tBuOOH; 4A MS / Ti(OiPr)4 / CH2Cl2 / 336 h / -25 °C
2.2: SO3*pyridine; triethylamine; DMSO / CH2Cl2 / 1 h / 0 °C
2.3: 745 mg / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1.5 h / 0 °C
With
tert.-butylhydroperoxide; sodium tetrahydroborate; hydrogen; (+)-Weinsaeure-diethylester; ethylenediamine;
titanium(IV) isopropylate; nickel diacetate;
In
methanol; dichloromethane;
2.1: Sharpless asymmetric epoxidation / 2.2: Parikh-Doering oxidation / 2.3: direct Wittig olefination;
DOI:10.1021/jo049505o
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 82 percent / NaBH4; ethylene-diamine; hydrogen / Ni(OAc)2*4H2O / methanol / 5 h / 20 °C
2.1: (+)-diethyl tartrate; tBuOOH; 4A MS / Ti(OiPr)4 / CH2Cl2 / 336 h / -25 °C
2.2: SO3*pyridine; triethylamine; DMSO / CH2Cl2 / 1 h / 0 °C
2.3: 745 mg / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1.5 h / 0 °C
3.1: 35 percent / Cu(OTf)2 / CH2Cl2 / 1 h / 20 °C
With
tert.-butylhydroperoxide; sodium tetrahydroborate; hydrogen; (+)-Weinsaeure-diethylester; ethylenediamine;
titanium(IV) isopropylate; nickel diacetate; copper(II) bis(trifluoromethanesulfonate);
In
methanol; dichloromethane;
2.1: Sharpless asymmetric epoxidation / 2.2: Parikh-Doering oxidation / 2.3: direct Wittig olefination;
DOI:10.1021/jo049505o
