(S)-2-((S)-2-Isopropoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid

Base Information

• Chemical Name: (S)-2-((S)-2-Isopropoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid
• CAS No.: 628729-13-5
• Molecular Formula: C₁₈H₂₆N₂O₅
• Molecular Weight: 350.415
• Mol file: 628729-13-5.mol

Synonyms:(S)-2-((S)-2-Isopropoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid

Chemical Property of (S)-2-((S)-2-Isopropoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-Isopropoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid

There total 5 articles about (S)-2-((S)-2-Isopropoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(S)-2-((S)-2-Isopropoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid methyl ester (628729-12-4) → (S)-2-((S)-2-Isopropoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid (628729-13-5)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1016/S0960-894X(03)00753-4

Reference yield:

L-valine benzyl ester hydrochloride (2462-34-2) → (S)-2-((S)-2-Isopropoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid (628729-13-5)

Guidance literature:

Multi-step reaction with 4 steps

1: i-Pr₂EtN

2: 100 percent / H₂ / Pd/C

3: 78 percent / HOAt; DCC; i-Pr₂EtN

4: 93 percent / aq. NaOH / methanol

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol;

DOI:10.1016/S0960-894X(03)00753-4

Reference yield:

(S)-2-Isopropoxycarbonylamino-3-methyl-butyric acid benzyl ester (628729-15-7) → (S)-2-((S)-2-Isopropoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid (628729-13-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C

2: 78 percent / HOAt; DCC; i-Pr₂EtN

3: 93 percent / aq. NaOH / methanol

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol;

DOI:10.1016/S0960-894X(03)00753-4

upstream raw materials:

(S)-2-((S)-2-Isopropoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid methyl ester

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

L-valine benzyl ester hydrochloride

N-isopropoxycarbonyl-S-valine