2-ethyl-3-hydroxy-17β-(2-tert-butyldiphenylsilyloxyethyl)estra-1,3,5(10)-triene

Base Information

Chemical Name:2-ethyl-3-hydroxy-17β-(2-tert-butyldiphenylsilyloxyethyl)estra-1,3,5(10)-triene
CAS No.:767351-91-7
Molecular Formula:C₃₈H₅₀O₂Si
Molecular Weight:566.899
Hs Code.:

Synonyms:2-ethyl-3-hydroxy-17β-(2-tert-butyldiphenylsilyloxyethyl)estra-1,3,5(10)-triene

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Chemical Property of 2-ethyl-3-hydroxy-17β-(2-tert-butyldiphenylsilyloxyethyl)estra-1,3,5(10)-triene

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Technology Process of 2-ethyl-3-hydroxy-17β-(2-tert-butyldiphenylsilyloxyethyl)estra-1,3,5(10)-triene

There total 6 articles about 2-ethyl-3-hydroxy-17β-(2-tert-butyldiphenylsilyloxyethyl)estra-1,3,5(10)-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 767351-90-6
2-ethyl-3-O-benzyl-17β-(2-(OTBDPS)ethyl) 17-deoxy estrone

: 767351-91-7
2-ethyl-3-hydroxy-17β-(2-tert-butyldiphenylsilyloxyethyl)estra-1,3,5(10)-triene

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol;

Reference yield:

: 2-ethyl-3-benzyloxy-17-(2-ethoxy-2-oxoethylidene)estra-1,3,5⁽¹⁰⁾-triene

: 767351-91-7
2-ethyl-3-hydroxy-17β-(2-tert-butyldiphenylsilyloxyethyl)estra-1,3,5(10)-triene

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 24 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 24 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm200483x

Reference yield:

: 767352-12-5
(3-benzyloxy-2-ethyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)-acetic acid ethyl ester

: 767351-91-7
2-ethyl-3-hydroxy-17β-(2-tert-butyldiphenylsilyloxyethyl)estra-1,3,5(10)-triene

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 24 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm200483x