3-cyclohexyl-N-(6'-fluoro-3-nitro-2'-trifluoromethylbiphenyl-4-yl)acrylamide

Base Information

• Chemical Name: 3-cyclohexyl-N-(6'-fluoro-3-nitro-2'-trifluoromethylbiphenyl-4-yl)acrylamide
• CAS No.: 1255710-81-6
• Molecular Formula: C₂₂H₂₀F₄N₂O₃
• Molecular Weight: 436.406
• Mol file: 1255710-81-6.mol

Synonyms:3-cyclohexyl-N-(6'-fluoro-3-nitro-2'-trifluoromethylbiphenyl-4-yl)acrylamide

Chemical Property of 3-cyclohexyl-N-(6'-fluoro-3-nitro-2'-trifluoromethylbiphenyl-4-yl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-cyclohexyl-N-(6'-fluoro-3-nitro-2'-trifluoromethylbiphenyl-4-yl)acrylamide

There total 6 articles about 3-cyclohexyl-N-(6'-fluoro-3-nitro-2'-trifluoromethylbiphenyl-4-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-fluoro-3-nitro-6'-(trifluoromethyl)-[1,1'-biphenyl]-4-amine (1221350-00-0) + 3-cyclohexyl-acryloyl chloride (52331-62-1) → 3-cyclohexyl-N-(6'-fluoro-3-nitro-2'-trifluoromethylbiphenyl-4-yl)acrylamide (1255710-81-6)

Guidance literature:

2'-fluoro-3-nitro-6'-(trifluoromethyl)-[1,1'-biphenyl]-4-amine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

3-cyclohexyl-acryloyl chloride; In N,N-dimethyl-formamide;

Reference yield:

cyclohexanecarbaldehyde (2043-61-0) → 3-cyclohexyl-N-(6'-fluoro-3-nitro-2'-trifluoromethylbiphenyl-4-yl)acrylamide (1255710-81-6)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / pyridine / 70 °C

2: oxalyl dichloride; N,N-dimethyl-formamide

3: sodium hydride / tetrahydrofuran / 0 °C

With piperidine; oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; pyridine;

DOI:10.1016/j.bmcl.2012.01.060

Reference yield:

4-amino-3-nitrophenylboronic acid pinacol ester (833486-94-5) → 3-cyclohexyl-N-(6'-fluoro-3-nitro-2'-trifluoromethylbiphenyl-4-yl)acrylamide (1255710-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane / 95 °C

2: sodium hydride / tetrahydrofuran / 0 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2012.01.060

upstream raw materials:

2'-fluoro-3-nitro-6'-(trifluoromethyl)-[1,1'-biphenyl]-4-amine

3-cyclohexyl-acryloyl chloride

4-amino-3-nitrophenylboronic acid pinacol ester

3-cyclohexylacrylic acid

Downstream raw materials:

2-(2-cyclohexylvinyl)-5-(2-fluoro-6-trifluoromethylphenyl)-1H-benzimidazole