3(RS)-tert-butyloxycarbonyl-6-phenyl-2(R)-isobutylhexanoic acid

Base Information

• Chemical Name: 3(RS)-tert-butyloxycarbonyl-6-phenyl-2(R)-isobutylhexanoic acid
• CAS No.: 184948-26-3
• Molecular Formula: C₂₁H₃₂O₄
• Molecular Weight: 348.483
• Mol file: 184948-26-3.mol

Synonyms:3(RS)-tert-butyloxycarbonyl-6-phenyl-2(R)-isobutylhexanoic acid

Chemical Property of 3(RS)-tert-butyloxycarbonyl-6-phenyl-2(R)-isobutylhexanoic acid

Chemical Property:

Purity/Quality:

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Technology Process of 3(RS)-tert-butyloxycarbonyl-6-phenyl-2(R)-isobutylhexanoic acid

There total 2 articles about 3(RS)-tert-butyloxycarbonyl-6-phenyl-2(R)-isobutylhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C27H41NO5 (1049037-35-5) → 3(RS)-tert-butyloxycarbonyl-6-phenyl-2(R)-isobutylhexanoic acid (184948-26-3)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 - 25 ℃; for 36h; Inert atmosphere;

DOI:10.1021/ja804159y

Reference yield: 43.0%

dibenzyl 3(RS)-tert-butyloxycarbonyl-3-cinnamyl-2(R)-isobutylsuccinate (184948-25-2) → 3(RS)-tert-butyloxycarbonyl-6-phenyl-2(R)-isobutylhexanoic acid (184948-26-3)

Guidance literature:

dibenzyl 3(RS)-tert-butyloxycarbonyl-3-cinnamyl-2(R)-isobutylsuccinate; With hydrogen; 5%-palladium/activated carbon; In ethanol; at 20 ℃; for 7h;

With 4-methyl-morpholine; In toluene; for 15h; Heating / reflux;

Reference yield: 92.0%

L-4'-(benzyloxycarbonylaminomethyl)-phenylalanine methyl ester 1 hydrochloride + 3(RS)-tert-butyloxycarbonyl-6-phenyl-2(R)-isobutylhexanoic acid (184948-26-3) → Na-[4-tert-butoxy-2(R)-isobutyl-3(S)-(3-phenylpropyl)-succinyl]-L-4'-(benzyloxycarbonylaminomethyl)phenylalanine methyl ester

Guidance literature:

With benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine;

upstream raw materials:

dibenzyl 3(RS)-tert-butyloxycarbonyl-3-cinnamyl-2(R)-isobutylsuccinate

C₂₇H₄₁NO₅