2-[(4R,6S)-6-((R)-1-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propan-2-ol

Base Information

Chemical Name:2-[(4R,6S)-6-((R)-1-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propan-2-ol
CAS No.:169392-06-7
Molecular Formula:C₁₈H₂₈O₄
Molecular Weight:308.418
Hs Code.:

Synonyms:2-[(4R,6S)-6-((R)-1-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propan-2-ol

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Chemical Property of 2-[(4R,6S)-6-((R)-1-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propan-2-ol

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Technology Process of 2-[(4R,6S)-6-((R)-1-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propan-2-ol

There total 7 articles about 2-[(4R,6S)-6-((R)-1-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 917-54-4
methyllithium

: 1-[(4R,6S)-6-((R)-1-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethanone

: 169392-06-7
2-[(4R,6S)-6-((R)-1-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propan-2-ol

Guidance literature:: In tetrahydrofuran; at -78 ℃;
DOI:10.1246/cl.1995.881

Reference yield:

: (2R,5R)-5-Benzyloxy-1,1-bis-ethylsulfanyl-hexan-2-ol

: 169392-06-7
2-[(4R,6S)-6-((R)-1-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / TsOH / CH₂Cl₂ / 0 °C

2: 98 percent / MeI, NaHCO₃ / H₂O; tetrahydrofuran

3: 78 percent / tetrahydrofuran / -78 °C

4: 94 percent / Swern reagent

5: 99 percent / tetrahydrofuran / -78 °C

With swern reagent; sodium hydrogencarbonate; toluene-4-sulfonic acid; methyl iodide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1246/cl.1995.881

Reference yield:

: (2R,5R)-5-Benzyloxy-hexane-1,1,2-triol

: 169392-06-7
2-[(4R,6S)-6-((R)-1-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / Ambient temperature

2: 94 percent / TsOH / CH₂Cl₂ / 0 °C

3: 98 percent / MeI, NaHCO₃ / H₂O; tetrahydrofuran

4: 78 percent / tetrahydrofuran / -78 °C

5: 94 percent / Swern reagent

6: 99 percent / tetrahydrofuran / -78 °C

With swern reagent; sodium hydrogencarbonate; toluene-4-sulfonic acid; methyl iodide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1246/cl.1995.881