H_4a,H₅-cis,H_4a,H_9b-cis-1-methyl-5-(4-aminophenyl)-2,3,4,4a,5,9b-hexahydro-1H-indeno<1,2-b>pyridin-2-one

Base Information

• Chemical Name: H_4a,H₅-cis,H_4a,H_9b-cis-1-methyl-5-(4-aminophenyl)-2,3,4,4a,5,9b-hexahydro-1H-indeno<1,2-b>pyridin-2-one
• CAS No.: 88687-52-9
• Molecular Formula: C₁₉H₂₀N₂O
• Molecular Weight: 292.381

Synonyms:H_4a,H₅-cis,H_4a,H_9b-cis-1-methyl-5-(4-aminophenyl)-2,3,4,4a,5,9b-hexahydro-1H-indeno<1,2-b>pyridin-2-one

Chemical Property of H_4a,H₅-cis,H_4a,H_9b-cis-1-methyl-5-(4-aminophenyl)-2,3,4,4a,5,9b-hexahydro-1H-indeno<1,2-b>pyridin-2-one

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Technology Process of H_4a,H₅-cis,H_4a,H_9b-cis-1-methyl-5-(4-aminophenyl)-2,3,4,4a,5,9b-hexahydro-1H-indeno<1,2-b>pyridin-2-one

There total 2 articles about H_4a,H₅-cis,H_4a,H_9b-cis-1-methyl-5-(4-aminophenyl)-2,3,4,4a,5,9b-hexahydro-1H-indeno<1,2-b>pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

3-[1-[(E)-Methylimino]-3-(4-nitro-phenyl)-indan-2-yl]-propionic acid → H4a,H5-cis,H4a,H9b-cis-1-methyl-5-(4-aminophenyl)-2,3,4,4a,5,9b-hexahydro-1H-indeno<1,2-b>pyridin-2-one (88687-52-9)

Guidance literature:

With hydrogen; nickel; In methanol; 1.) 50 deg C, 50 atm, 2 h, 2.) 90 deg C, 100 atm, 18 h;

DOI:10.1021/jm00370a004

Reference yield:

3-[3-(4-nitrophenyl)-indane-1-one-2-yl]-propionic acid (88687-53-0) → H4a,H5-cis,H4a,H9b-cis-1-methyl-5-(4-aminophenyl)-2,3,4,4a,5,9b-hexahydro-1H-indeno<1,2-b>pyridin-2-one (88687-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 15 h / Ambient temperature

2: 19 percent / H₂ / Raney nickel / methanol / 1.) 50 deg C, 50 atm, 2 h, 2.) 90 deg C, 100 atm, 18 h

With hydrogen; nickel; In methanol;

DOI:10.1021/jm00370a004

Reference yield:

H4a,H5-cis,H4a,H9b-cis-1-methyl-5-(4-aminophenyl)-2,3,4,4a,5,9b-hexahydro-1H-indeno<1,2-b>pyridin-2-one (88687-52-9) → 4-((4aR,5R,9bR)-1-Methyl-2,3,4,4a,5,9b-hexahydro-1H-indeno[1,2-b]pyridin-5-yl)-phenylamine (88763-09-1)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1021/jm00370a004

upstream raw materials:

3-[3-(4-nitrophenyl)-indane-1-one-2-yl]-propionic acid

Downstream raw materials:

4-((4aR,5R,9bR)-1-Methyl-2,3,4,4a,5,9b-hexahydro-1H-indeno[1,2-b]pyridin-5-yl)-phenylamine

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