(S)-(N'-benzoylhydrazino)-(4-dimethylamino-2-methoxyphenyl)-acetic acid isopropyl ester

Base Information

Chemical Name:(S)-(N'-benzoylhydrazino)-(4-dimethylamino-2-methoxyphenyl)-acetic acid isopropyl ester
CAS No.:849097-60-5
Molecular Formula:C₂₁H₂₇N₃O₄
Molecular Weight:385.463
Hs Code.:

Synonyms:(S)-(N'-benzoylhydrazino)-(4-dimethylamino-2-methoxyphenyl)-acetic acid isopropyl ester

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Chemical Property of (S)-(N'-benzoylhydrazino)-(4-dimethylamino-2-methoxyphenyl)-acetic acid isopropyl ester

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Technology Process of (S)-(N'-benzoylhydrazino)-(4-dimethylamino-2-methoxyphenyl)-acetic acid isopropyl ester

There total 4 articles about (S)-(N'-benzoylhydrazino)-(4-dimethylamino-2-methoxyphenyl)-acetic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 15799-79-8
3-methoxy-N,N-dimethylaniline

: (benzoylhydrazono)acetic acid isopropyl ester

: 849097-60-5
(S)-(N'-benzoylhydrazino)-(4-dimethylamino-2-methoxyphenyl)-acetic acid isopropyl ester

Guidance literature:: (benzoylhydrazono)acetic acid isopropyl ester; With (4S,5S)-2-Chloro-3,4-dimethyl-2,5-diphenyl-[1,3,2]oxazasilolidine; In toluene; at -30 ℃; for 0.25h;

3-methoxy-N,N-dimethylaniline; In toluene; at -30 ℃; for 45h;

With water; In toluene;

Reference yield:

: 15799-79-8
3-methoxy-N,N-dimethylaniline

: (benzoylhydrazono)acetic acid isopropyl ester

: 849097-60-5
(S)-(N'-benzoylhydrazino)-(4-dimethylamino-2-methoxyphenyl)-acetic acid isopropyl ester

: (R)-(N'-benzoylhydrazino)-(4-dimethylamino-2-methoxyphenyl)acetic acid isopropyl ester

Guidance literature:: With simple strained silacycle chiral reagent; In toluene; at -30 ℃; for 45h; Title compound not separated from byproducts;
DOI:10.1021/ja042522a

Reference yield:

: 2217-15-4
L-(+)-diisopropyl tartrate

: 849097-60-5
(S)-(N'-benzoylhydrazino)-(4-dimethylamino-2-methoxyphenyl)-acetic acid isopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaIO₄ / 2 h / 0 °C

2: 14.8 g / ethanol / 12 h

3: simple strained silacycle chiral reagent / toluene / 45 h / -30 °C

With sodium periodate; simple strained silacycle chiral reagent; In ethanol; toluene; 3: Friedel-Crafts reaction;
DOI:10.1021/ja042522a