5-[(R)-2-Ethyl-5-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

Base Information

Chemical Name:5-[(R)-2-Ethyl-5-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole
CAS No.:719282-41-4
Molecular Formula:C₂₄H₃₆N₄O₄S
Molecular Weight:476.64
Hs Code.:

Synonyms:5-[(R)-2-Ethyl-5-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

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Chemical Property of 5-[(R)-2-Ethyl-5-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

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Technology Process of 5-[(R)-2-Ethyl-5-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

There total 8 articles about 5-[(R)-2-Ethyl-5-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 719282-45-8
(R)-2-Ethyl-5-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentan-1-ol

: 719282-41-4
5-[(R)-2-Ethyl-5-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: (R)-2-Ethyl-5-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentan-1-ol; With p-toluenesulfonyl chloride; In triethylamine;

1-Phenyl-1H-tetrazole-5-thiol; With potassium tert-butylate;

With ammonium heptamolybdate; dihydrogen peroxide; Further stages.;
DOI:10.1016/j.tetlet.2004.03.169

Reference yield:

: 130710-56-4
(S)-3-<(R)-2-ethyl-1-oxo-4-penten-1-yl>-4-(phenylmethyl)-1,3-oxazolidin-2-one

: 719282-41-4
5-[(R)-2-Ethyl-5-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: LiBH₄

1.2: 73 percent / MS 4A; imidazole

2.1: OsO₄; NMO; NaIO₄

2.2: NaBH₄

3.1: n-Bu₃P

3.2: 100 percent / mCPBA

4.1: n-BuLi

4.2: Ac₂O; DMAP / pyridine

4.3: 70 percent / Na/Hg; Na₂HPO₄

5.1: 91 percent / H₂ / Pd(OH)2/C

6.1: 95 percent / TBAF

7.1: TsCl / triethylamine

7.2: t-BuOK

7.3: 73 percent / (NH₄)6Mo₇O₂₄*4H₂O; H₂O₂

With sodium periodate; osmium(VIII) oxide; lithium borohydride; n-butyllithium; N-methyl-2-indolinone; tributylphosphine; tetrabutyl ammonium fluoride; hydrogen; p-toluenesulfonyl chloride; palladium dihydroxide; In triethylamine; 2.1: Lemieux-Johnson oxidation;
DOI:10.1016/j.tetlet.2004.03.169

Reference yield:

: 141521-22-4
(R)-2-Ethyl-1,4-dioxa-spiro[4.5]decane-2-carbaldehyde

: 719282-41-4
5-[(R)-2-Ethyl-5-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi

1.2: Ac₂O; DMAP / pyridine

1.3: 70 percent / Na/Hg; Na₂HPO₄

2.1: 91 percent / H₂ / Pd(OH)2/C

3.1: 95 percent / TBAF

4.1: TsCl / triethylamine

4.2: t-BuOK

4.3: 73 percent / (NH₄)6Mo₇O₂₄*4H₂O; H₂O₂

With n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; p-toluenesulfonyl chloride; palladium dihydroxide; In triethylamine;
DOI:10.1016/j.tetlet.2004.03.169