2-amino-2-[3-fluoro-5-(trifluoromethyl)phenyl]-1-azavinyl (2S)-2-acetyloxypropanoate

Base Information

Chemical Name:2-amino-2-[3-fluoro-5-(trifluoromethyl)phenyl]-1-azavinyl (2S)-2-acetyloxypropanoate
CAS No.:1050239-66-1
Molecular Formula:C₁₃H₁₂F₄N₂O₄
Molecular Weight:336.243
Hs Code.:

Synonyms:2-amino-2-[3-fluoro-5-(trifluoromethyl)phenyl]-1-azavinyl (2S)-2-acetyloxypropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-2-[3-fluoro-5-(trifluoromethyl)phenyl]-1-azavinyl (2S)-2-acetyloxypropanoate

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Technology Process of 2-amino-2-[3-fluoro-5-(trifluoromethyl)phenyl]-1-azavinyl (2S)-2-acetyloxypropanoate

There total 3 articles about 2-amino-2-[3-fluoro-5-(trifluoromethyl)phenyl]-1-azavinyl (2S)-2-acetyloxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885956-71-8
3-fluoro-N'-hydroxy-5-(trifluoromethyl)benzimidamide

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

: 1050239-66-1
2-amino-2-[3-fluoro-5-(trifluoromethyl)phenyl]-1-azavinyl (2S)-2-acetyloxypropanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

Reference yield:

: of(1S)-1-(chlorocarbonyl)ethyl acetate

: 885956-71-8
[5-fluoro-3-(trifluoromethyl)-phenyl](hydroxyimino)methylamine

: 1050239-66-1
2-amino-2-[3-fluoro-5-(trifluoromethyl)phenyl]-1-azavinyl (2S)-2-acetyloxypropanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

Reference yield:

: 149793-69-1
3-fluoro-5-trifluoromethyl-benzonitrile

: 1050239-66-1
2-amino-2-[3-fluoro-5-(trifluoromethyl)phenyl]-1-azavinyl (2S)-2-acetyloxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine / ethanol; water / 2 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 - 20 °C

With hydroxylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water;