2-(2-fluorobiphenyl-4-yl)-N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]propanamide

Base Information

• Chemical Name: 2-(2-fluorobiphenyl-4-yl)-N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]propanamide
• CAS No.: 1430219-37-6
• Molecular Formula: C₃₆H₄₂FN₃O
• Molecular Weight: 551.747

Synonyms:2-(2-fluorobiphenyl-4-yl)-N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]propanamide

Chemical Property of 2-(2-fluorobiphenyl-4-yl)-N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]propanamide

Chemical Property:

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Technology Process of 2-(2-fluorobiphenyl-4-yl)-N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]propanamide

There total 4 articles about 2-(2-fluorobiphenyl-4-yl)-N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

fluorobiprofen (5104-49-4) + N-(1,2,3,4-tetrahydroacridin-9-yl)octane-1,8-diamine (249290-19-5) → 2-(2-fluorobiphenyl-4-yl)-N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]propanamide (1430219-37-6)

Guidance literature:

fluorobiprofen; With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 0.5h;

N-(1,2,3,4-tetrahydroacridin-9-yl)octane-1,8-diamine; With dmap; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/ardp.201300074

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 2-(2-fluorobiphenyl-4-yl)-N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]propanamide (1430219-37-6)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / Reflux

2: pentan-1-ol / 18 h / Reflux

3: dicyclohexyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; trichlorophosphate; In dichloromethane; pentan-1-ol; 1: |Friedel-Crafts Alkylation;

DOI:10.1016/j.bmcl.2013.04.008

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 2-(2-fluorobiphenyl-4-yl)-N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]propanamide (1430219-37-6)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / Reflux

2: pentan-1-ol / 18 h / Reflux

3: dicyclohexyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; trichlorophosphate; In dichloromethane; pentan-1-ol; 1: |Friedel-Crafts Alkylation;

DOI:10.1016/j.bmcl.2013.04.008

upstream raw materials:

anthranilic acid

cyclohexanone

9-chloro-1,2,3,4-tetrahydroacridine

fluorobiprofen

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