8-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

Base Information

Chemical Name:8-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide
CAS No.:1197329-93-3
Molecular Formula:C₂₉H₂₉Cl₂N₅O₃
Molecular Weight:566.487
Hs Code.:

Synonyms:8-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

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Chemical Property of 8-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

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Technology Process of 8-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

There total 13 articles about 8-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197331-89-7
8-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid

: 115619-01-7
4-(4-ethylpiperazin-1-yl)aniline

: 1197329-93-3
8-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

Guidance literature:: With propylphosphonic anhydride; triethylamine; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 5308-25-8
4-ethylpiperazine

: 1197329-93-3
8-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 15 h / 80 °C

2: hydrogen / nickel / methanol / 7 h / 20 °C

3: propylphosphonic anhydride; triethylamine / dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With propylphosphonic anhydride; hydrogen; triethylamine; dmap; nickel; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1197331-92-2
5-bromo-8-(3,5-dimethoxy-phenyl)-quinoxaline

: 1197329-93-3
8-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-methyl-pyrrolidin-2-one / 2 h / 180 °C / Inert atmosphere

2.1: potassium hydroxide / ethylene glycol / 3 h / 150 °C

2.2: pH 5

3.1: sulfuryl dichloride / acetonitrile / 2 h / 5 °C

4.1: propylphosphonic anhydride; triethylamine / dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With sulfuryl dichloride; propylphosphonic anhydride; triethylamine; potassium hydroxide; dmap; In 1-methyl-pyrrolidin-2-one; ethylene glycol; N,N-dimethyl-formamide; acetonitrile;