1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI)

Base Information

• Chemical Name: 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI)
• CAS No.: 190141-99-2
• Molecular Formula: C9H18 N2 O3
• Molecular Weight: 202.254
• Hs Code.: 2933990090
• Mol file: 190141-99-2.mol

Synonyms:3-Amino-4-hydroxypyrrolidine-1-carboxylicacid tert-butyl ester; tert-Butyl 3-amino-4-hydroxy-1-pyrrolidinecarboxylate

Chemical Property of 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI)

Chemical Property:

• Boiling Point: 309℃
• PKA: 14.36±0.40(Predicted)
• Flash Point: 141℃
• PSA: 75.79000
• Density: 1.179
• LogP: 0.56350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-amino-4-hydroxypyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI)

There total 5 articles about 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-tert-butoxycarbonyl-3,4-epoxypyrrolidine (114214-49-2) → [trans-]-3-amino-4-hydroxy-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester (190141-99-2,138026-97-8,148214-90-8,190792-75-7)

Guidance literature:

With ammonia; In water; at 70 ℃; Sealed tube;

Reference yield: 90.0%

(±)-tert-butyl 3-azido-4-hydroxypyrrolidine-1-carboxylate (203434-45-1) → [trans-]-3-amino-4-hydroxy-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester (190141-99-2,138026-97-8,148214-90-8,190792-75-7)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran;

DOI:10.1016/S0960-894X(97)10222-0

Reference yield:

[trans-(+/-)]-3-hydroxy-4-[(phenylmethyl)amino]-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester → [trans-]-3-amino-4-hydroxy-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester (190141-99-2,138026-97-8,148214-90-8,190792-75-7)

Guidance literature:

palladium; In ethanol; ethyl acetate;

upstream raw materials:

(±)-tert-butyl 3-azido-4-hydroxypyrrolidine-1-carboxylate

N-(tert-butoxycarbonyl)-3-pyrroline

1-tert-butoxycarbonyl-3,4-epoxypyrrolidine

di-tert-butyl dicarbonate

Downstream raw materials:

(3R,S)-((S)-2-benzyloxycarbonylamino-4-methylpentanoylamino)-(4R,S)-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester

tert-butyl 3-(3-cyanobenzamido)-4-hydroxypyrrolidine-1-carboxylate

3,4-diaminopyrrolidinyl-1-carboxylic acid tert-butyl ester

(3S,4S)-3-amino-4-hydroxypyrrolidine dihydrochloride

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