(S)-methyl 2-(1-(4-(2'-fluorobiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetate

Base Information

Chemical Name:(S)-methyl 2-(1-(4-(2'-fluorobiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetate
CAS No.:1283146-87-1
Molecular Formula:C₂₅H₂₄FNO₃
Molecular Weight:405.469
Hs Code.:

Synonyms:(S)-methyl 2-(1-(4-(2'-fluorobiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetate

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Chemical Property of (S)-methyl 2-(1-(4-(2'-fluorobiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetate

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Technology Process of (S)-methyl 2-(1-(4-(2'-fluorobiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetate

There total 7 articles about (S)-methyl 2-(1-(4-(2'-fluorobiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1283146-85-9
(S)-methyl 2-(1-(4-(3-bromophenoxy)phenyl)pyrrolidin-2-yl)acetate

: 1993-03-9
o-fluorophenylboronic acid

: 1283146-87-1
(S)-methyl 2-(1-(4-(2'-fluorobiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In methanol; water; toluene; at 95 ℃; for 3.7h; Inert atmosphere;

Reference yield:

: 19578-68-8
4-(4-benzyloxyphenyl) iodide

: 1283146-87-1
(S)-methyl 2-(1-(4-(2'-fluorobiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / copper(l) iodide / isopropyl alcohol / 90 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 0 °C

3: dimethyl sulfoxide / 4 h / 50 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

5: hydrogenchloride / methanol; dichloromethane / 0 - 20 °C

6: pyridine / copper diacetate / dichloromethane / 24 h / 20 °C / Molecular sieve; Inert atmosphere

7: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / methanol; water; toluene / 3.7 h / 95 °C / Inert atmosphere

With pyridine; hydrogenchloride; hydrogen; sodium carbonate; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; copper diacetate; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; toluene;

Reference yield:

: 1283147-14-7
(S)-2-(1-(4-hydroxyphenyl)pyrrolidin-2-yl)acetonitrile

: 1283146-87-1
(S)-methyl 2-(1-(4-(2'-fluorobiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol; dichloromethane / 0 - 20 °C

2: pyridine / copper diacetate / dichloromethane / 24 h / 20 °C / Molecular sieve; Inert atmosphere

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / methanol; water; toluene / 3.7 h / 95 °C / Inert atmosphere

With pyridine; hydrogenchloride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper diacetate; In methanol; dichloromethane; water; toluene;