1-[2(S)-hydroxy-3(S)-(N-(methoxycarbonyl)-(L)-valyl)amino-4-phenyl-butyl]-1-[cyclohexylmethyl]-2-[N-methoxycarbonyl-(L)-valyl]-hydrazine

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Chemical Name:1-[2(S)-hydroxy-3(S)-(N-(methoxycarbonyl)-(L)-valyl)amino-4-phenyl-butyl]-1-[cyclohexylmethyl]-2-[N-methoxycarbonyl-(L)-valyl]-hydrazine
CAS No.:161968-14-5
Molecular Formula:C₃₁H₅₁N₅O₇
Molecular Weight:605.775
Hs Code.:

Synonyms:1-[2(S)-hydroxy-3(S)-(N-(methoxycarbonyl)-(L)-valyl)amino-4-phenyl-butyl]-1-[cyclohexylmethyl]-2-[N-methoxycarbonyl-(L)-valyl]-hydrazine

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Chemical Property of 1-[2(S)-hydroxy-3(S)-(N-(methoxycarbonyl)-(L)-valyl)amino-4-phenyl-butyl]-1-[cyclohexylmethyl]-2-[N-methoxycarbonyl-(L)-valyl]-hydrazine

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Technology Process of 1-[2(S)-hydroxy-3(S)-(N-(methoxycarbonyl)-(L)-valyl)amino-4-phenyl-butyl]-1-[cyclohexylmethyl]-2-[N-methoxycarbonyl-(L)-valyl]-hydrazine

There total 7 articles about 1-[2(S)-hydroxy-3(S)-(N-(methoxycarbonyl)-(L)-valyl)amino-4-phenyl-butyl]-1-[cyclohexylmethyl]-2-[N-methoxycarbonyl-(L)-valyl]-hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929016-50-2
(E)-tert-butyl 2-(cyclohexylmethylene)hydrazinecarboxylate

: 161968-14-5
1-[2(S)-hydroxy-3(S)-(N-(methoxycarbonyl)-(L)-valyl)amino-4-phenyl-butyl]-1-[cyclohexylmethyl]-2-[N-methoxycarbonyl-(L)-valyl]-hydrazine

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / H₂ / 5percent Pt/C / methanol / 8 h / 760 Torr / Ambient temperature

2: 55.4 percent / methanol / 16 h / Heating

3: 90 percent / 4N HCl(gas)/dioxane / 6 h / Ambient temperature

4: 1.) 1-hydroxybenzotriazole hydrate, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, 4-methylmorpholine / 1.) DMF, 15 min, 2.) DMF, RT, overnight

With 1,4-dioxane; 4-methyl-morpholine; hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1-hydroxybenzotriazol-hydrate; platinum on activated charcoal; In methanol;
DOI:10.1021/jm960022p

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 161968-14-5
1-[2(S)-hydroxy-3(S)-(N-(methoxycarbonyl)-(L)-valyl)amino-4-phenyl-butyl]-1-[cyclohexylmethyl]-2-[N-methoxycarbonyl-(L)-valyl]-hydrazine

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / ethanol / 3 h / Heating

2: 95 percent / H₂ / 5percent Pt/C / methanol / 8 h / 760 Torr / Ambient temperature

3: 55.4 percent / methanol / 16 h / Heating

4: 90 percent / 4N HCl(gas)/dioxane / 6 h / Ambient temperature

5: 1.) 1-hydroxybenzotriazole hydrate, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, 4-methylmorpholine / 1.) DMF, 15 min, 2.) DMF, RT, overnight

With 1,4-dioxane; 4-methyl-morpholine; hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1-hydroxybenzotriazol-hydrate; platinum on activated charcoal; In methanol; ethanol;
DOI:10.1021/jm960022p

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 161968-14-5
1-[2(S)-hydroxy-3(S)-(N-(methoxycarbonyl)-(L)-valyl)amino-4-phenyl-butyl]-1-[cyclohexylmethyl]-2-[N-methoxycarbonyl-(L)-valyl]-hydrazine

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / 2 N aq. NaOH / dioxane / 16 h / Ambient temperature

2: 1.) 1-hydroxybenzotriazole hydrate, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, 4-methylmorpholine / 1.) DMF, 15 min, 2.) DMF, RT, overnight

With 4-methyl-morpholine; sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1-hydroxybenzotriazol-hydrate; In 1,4-dioxane;
DOI:10.1021/jm960022p