(2S,3R)-3-(tert-butyldimethylsilyloxy)-2-methyl-4-phenylbutanal

Base Information

• Chemical Name: (2S,3R)-3-(tert-butyldimethylsilyloxy)-2-methyl-4-phenylbutanal
• CAS No.: 169944-42-7
• Molecular Formula: C₁₇H₂₈O₂Si
• Molecular Weight: 292.494
• Mol file: 169944-42-7.mol

Synonyms:(2S,3R)-3-(tert-butyldimethylsilyloxy)-2-methyl-4-phenylbutanal

Chemical Property of (2S,3R)-3-(tert-butyldimethylsilyloxy)-2-methyl-4-phenylbutanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-3-(tert-butyldimethylsilyloxy)-2-methyl-4-phenylbutanal

There total 1 articles about (2S,3R)-3-(tert-butyldimethylsilyloxy)-2-methyl-4-phenylbutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(((2R,3R)-3-benzyl-2-methyloxiran-2-yl)methoxy)(tert-butyl)dimethylsilane (1037435-27-0) + t-butyldimethylsiyl triflate (69739-34-0) → (2S,3R)-3-(tert-butyldimethylsilyloxy)-2-methyl-4-phenylbutanal (169944-42-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - -45 ℃;

DOI:10.1021/jo800574g

Reference yield:

(2S,3R)-3-(tert-butyldimethylsilyloxy)-2-methyl-4-phenylbutanal (169944-42-7) + (1-methyl-2-propenyl)diphenylphosphine oxide (13303-58-7) → (tert-butyl)((2R,3R,4Z)-3,5-dimethyl-1-phenylhepta-4,6-dien-2-yloxy)dimethylsilane (1037435-38-3) + (tert-butyl)((2R,3R,4E)-3,5-dimethyl-1-phenylhepta-4,6-dien-2-yloxy)dimethylsilane (1037435-28-1)

Guidance literature:

(1-methyl-2-propenyl)diphenylphosphine oxide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

(2S,3R)-3-(tert-butyldimethylsilyloxy)-2-methyl-4-phenylbutanal; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Further stages.;

DOI:10.1021/jo800574g

upstream raw materials:

(((2R,3R)-3-benzyl-2-methyloxiran-2-yl)methoxy)(tert-butyl)dimethylsilane

t-butyldimethylsiyl triflate

Downstream raw materials:

(tert-butyl)((2R,3R,4Z)-3,5-dimethyl-1-phenylhepta-4,6-dien-2-yloxy)dimethylsilane

(tert-butyl)((2R,3R,4E)-3,5-dimethyl-1-phenylhepta-4,6-dien-2-yloxy)dimethylsilane