8,9,10-Trihydroxy-7-(hydroxymethyl)-2-sulfanylidene-6-oxa-1,3-diazaspiro[4.5]decan-4-one

Base Information

Chemical Name:8,9,10-Trihydroxy-7-(hydroxymethyl)-2-sulfanylidene-6-oxa-1,3-diazaspiro[4.5]decan-4-one
CAS No.:189633-62-3
Molecular Formula:C₈H₁₂N₂O₆S
Molecular Weight:264.259
Hs Code.:
DSSTox Substance ID:DTXSID50394961
Mol file:189633-62-3.mol

Synonyms:8,9,10-Trihydroxy-7-(hydroxymethyl)-2-sulfanylidene-6-oxa-1,3-diazaspiro[4.5]decan-4-one;189633-62-3;(2R,3R,4S,5R,6S)-3,4,6-Trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-10-one-8-thione;(2R,3S,4S,5R,6S)-3,4,6-Trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-10-one-8-thione;227458-60-8;2R,3R,4S,5R,6S)-3,4,5-Trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-10-one-8-thione;SCHEMBL4330413;DTXSID50394961;PD042423

Suppliers and Price of 8,9,10-Trihydroxy-7-(hydroxymethyl)-2-sulfanylidene-6-oxa-1,3-diazaspiro[4.5]decan-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(2R-3R-4S-5R-6S)-3-4-5-Trihydroxy-2-hydroxymethyl-7-9-diaza-1-oxa-spiro[4-5]decane-10-one-8-thione
5 mg
$ 1429.00

Biosynth Carbosynth
(2R,3R,4S,5R,6S)-3,4,5-Trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-10-one-8-thione
2 mg
$ 420.00

Biosynth Carbosynth
(2R,3R,4S,5R,6S)-3,4,5-Trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-10-one-8-thione
1 mg
$ 262.50

Biosynth Carbosynth
(2R,3R,4S,5R,6S)-3,4,5-Trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-10-one-8-thione
5 mg
$ 1029.00

American Custom Chemicals Corporation
(2R,3R,4S,5R,6S)-3,4,5-TRIHYDROXY-2-HYDROXYMETHYL-7,9-DIAZA-1-OXA-SPIRO[4,5]DECANE-10-ONE-8-THIONE 95.00%
5MG
$ 503.02

Total 2 raw suppliers

Chemical Property of 8,9,10-Trihydroxy-7-(hydroxymethyl)-2-sulfanylidene-6-oxa-1,3-diazaspiro[4.5]decan-4-one

Chemical Property:

PSA：163.37000
LogP:-3.18160
XLogP3:-2.8
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:264.04160728
Heavy Atom Count:17
Complexity:366

Purity/Quality:

95% ^*data from raw suppliers

(2R-3R-4S-5R-6S)-3-4-5-Trihydroxy-2-hydroxymethyl-7-9-diaza-1-oxa-spiro[4-5]decane-10-one-8-thione ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(C1C(C(C(C2(O1)C(=O)NC(=S)N2)O)O)O)O

Technology Process of 8,9,10-Trihydroxy-7-(hydroxymethyl)-2-sulfanylidene-6-oxa-1,3-diazaspiro[4.5]decan-4-one

There total 8 articles about 8,9,10-Trihydroxy-7-(hydroxymethyl)-2-sulfanylidene-6-oxa-1,3-diazaspiro[4.5]decan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 286369-08-2
(2R,3R,4S,5R,6S)-3,4,5-tribenzoyloxy-2-benzoyloxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-10-one-8-thione

: 227458-60-8,189633-62-3
(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-10-one-8-thione

Guidance literature:: With methanol; sodium methylate; Heating;
DOI:10.1016/S0957-4166(99)00486-3

Reference yield: 78.0%

: 227458-59-5
(2R,3R,4S,5R,6S)-3,4,5-triacetoxy-2-acetoxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-10-one-8-thione

: 227458-60-8,189633-62-3
(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-10-one-8-thione

Guidance literature:: With sodium methylate; Ambient temperature;
DOI:10.1016/S0960-894X(99)00192-4

Reference yield:

: 82469-74-7
2,3,4,6-tetra-O-acetyl-1-deoxy-1-bromo-β-D-glycopyranosyl cyanide

: 227458-60-8,189633-62-3
(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-10-one-8-thione

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / TiCl₄; aq. AcOH / 144 h / 20 °C

2: 79 percent / S₈ / nitromethane / 4 h / 80 °C

3: 78 percent / NaOMe; MeOH / 20 °C

With methanol; sulfur; sodium methylate; titanium tetrachloride; acetic acid; In nitromethane;
DOI:10.1021/jm010892t