6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Base Information

Chemical Name:6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
CAS No.:1336960-35-0
Molecular Formula:C₃₆H₃₆ClF₃N₄O₂
Molecular Weight:649.156
Hs Code.:

Synonyms:6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

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Chemical Property of 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

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Technology Process of 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

There total 8 articles about 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1336964-74-9
6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 41049-53-0,773012-60-5
1-phenylcyclopropylamine

: 1336960-35-0
6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid; With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 60 ℃; for 5h;

1-phenylcyclopropylamine; In dichloromethane; at 20 - 80 ℃; for 18.3h; Microwave irradiation;

Reference yield:

: 106-47-8
4-chloro-aniline

: 1336960-35-0
6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate / water / 3 h / 20 °C / Reflux

2.1: sulfuric acid / 1 h / 70 °C

3.1: hydrogenchloride; acetic acid / water / 48 h / 75 - 110 °C

4.1: thionyl chloride / Heating

4.2: 18 h / 20 °C

5.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux

6.1: potassium carbonate / dichloromethane / 0.5 h / 20 °C

6.2: 24 h / 20 °C

7.1: hydrogenchloride / water / 1.5 h / Reflux

8.1: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 5 h / 60 °C

8.2: 18.3 h / 20 - 80 °C / Microwave irradiation

With hydrogenchloride; dmap; N-Bromosuccinimide; thionyl chloride; sulfuric acid; hydroxylamine hydrochloride; potassium carbonate; benzotriazol-1-ol; acetic acid; sodium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; water;

Reference yield:

: 17630-76-1
5-chloroindole 2,3-dione

: 1336960-35-0
6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; acetic acid / water / 48 h / 75 - 110 °C

2.1: thionyl chloride / Heating

2.2: 18 h / 20 °C

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux

4.1: potassium carbonate / dichloromethane / 0.5 h / 20 °C

4.2: 24 h / 20 °C

5.1: hydrogenchloride / water / 1.5 h / Reflux

6.1: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 5 h / 60 °C

6.2: 18.3 h / 20 - 80 °C / Microwave irradiation

With hydrogenchloride; dmap; N-Bromosuccinimide; thionyl chloride; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; water;