(S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid amide

Base Information

Chemical Name:(S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid amide
CAS No.:1359822-96-0
Molecular Formula:C₁₈H₂₃N₅O₃
Molecular Weight:357.412
Hs Code.:

Synonyms:(S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid amide

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Chemical Property of (S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid amide

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Technology Process of (S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid amide

There total 5 articles about (S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1359822-93-7
(S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid

: 1359822-96-0
(S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid amide

Guidance literature:: (S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; at -15 ℃; for 2h;

With ammonia; In acetonitrile; for 1h;

Reference yield:

: 201338-62-7
N,N-tert-butoxycarbonyldehydroalanine

: 1359822-96-0
(S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium tert-butoxide / tetrahydrofuran / -5 °C

1.2: 7 h / Reflux

1.3: 20 °C / pH 4

2.1: acetic acid butyl ester / 20 - 50 °C

3.1: water; sulfuric acid / isopropyl alcohol / 1 h / 20 °C

4.1: 1,1'-carbonyldiimidazole / acetonitrile / 2 h / -15 °C

4.2: 1 h

With sulfuric acid; water; 1,1'-carbonyldiimidazole; lithium tert-butoxide; In tetrahydrofuran; acetic acid butyl ester; isopropyl alcohol; acetonitrile;

Reference yield:

: 1359822-89-1
2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid

: 1359822-96-0
(S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid butyl ester / 20 - 50 °C

2.1: water; sulfuric acid / isopropyl alcohol / 1 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / acetonitrile / 2 h / -15 °C

3.2: 1 h

With sulfuric acid; water; 1,1'-carbonyldiimidazole; In acetic acid butyl ester; isopropyl alcohol; acetonitrile;