6-[3-(benzyloxycarbonylmethyl-tert-butoxycarbonyl-amino)-propionylamino]-hexanoic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:6-[3-(benzyloxycarbonylmethyl-tert-butoxycarbonyl-amino)-propionylamino]-hexanoic acid 2,2,2-trichloro-ethyl ester
CAS No.:870638-81-6
Molecular Formula:C₂₅H₃₅Cl₃N₂O₇
Molecular Weight:581.921
Hs Code.:

6-[3-(benzyloxycarbonylmethyl-<i>tert</i>-butoxycarbonyl-amino)-propionylamino]-hexanoic acid 2,2,2-trichloro-ethyl ester

Synonyms:6-[3-(benzyloxycarbonylmethyl-tert-butoxycarbonyl-amino)-propionylamino]-hexanoic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of 6-[3-(benzyloxycarbonylmethyl-tert-butoxycarbonyl-amino)-propionylamino]-hexanoic acid 2,2,2-trichloro-ethyl ester

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Technology Process of 6-[3-(benzyloxycarbonylmethyl-tert-butoxycarbonyl-amino)-propionylamino]-hexanoic acid 2,2,2-trichloro-ethyl ester

There total 2 articles about 6-[3-(benzyloxycarbonylmethyl-tert-butoxycarbonyl-amino)-propionylamino]-hexanoic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.3%

: 6-aminocapronic acid 2,2,2-trichloroethyl ester

: 870638-79-2
3-(benzyloxycarbonylmethyl-tert-butoxycarbonyl-amino)-propionic acid

: 870638-81-6
6-[3-(benzyloxycarbonylmethyl-tert-butoxycarbonyl-amino)-propionylamino]-hexanoic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1248/cpb.53.1131

Reference yield:

: 649728-20-1
3-(benzyloxycarbonylmethyl-tert-butoxycarbonyl-amino)-propionic acid 2,2,2-trichloro-ethyl ester

: 870638-81-6
6-[3-(benzyloxycarbonylmethyl-tert-butoxycarbonyl-amino)-propionylamino]-hexanoic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / zinc; acetic acid / 1 h / 20 °C

2: 72.3 percent / triethylamine; diethyl phosphorocyanidate / dimethylformamide / 16 h / 20 °C

With diethyl cyanophosphonate; acetic acid; triethylamine; zinc; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.1131

Reference yield:

: 870638-81-6
6-[3-(benzyloxycarbonylmethyl-tert-butoxycarbonyl-amino)-propionylamino]-hexanoic acid 2,2,2-trichloro-ethyl ester

: 870638-87-2
C₅₂H₅₉N₃O₁₆

Guidance literature:: Multi-step reaction with 3 steps

1: 93.7 percent / H₂ / Pd/C / tetrahydrofuran / 2 h / 20 °C

2: 79 percent / triethylamine; diethyl phosphorocyanidate / dimethylformamide / 16 h / 20 °C

3: 83.3 percent / zinc; acetic acid / 1 h / 20 °C

With diethyl cyanophosphonate; hydrogen; acetic acid; triethylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.1131