(S)-ethyl 3-(1-hydroxy-3-methylbutan-2-ylamino)-2-(5-iodo-2,4-dimethoxybenzoyl)acrylate

Base Information

Chemical Name:(S)-ethyl 3-(1-hydroxy-3-methylbutan-2-ylamino)-2-(5-iodo-2,4-dimethoxybenzoyl)acrylate
CAS No.:1598387-94-0
Molecular Formula:C₁₉H₂₆INO₆
Molecular Weight:491.323
Hs Code.:

Synonyms:(S)-ethyl 3-(1-hydroxy-3-methylbutan-2-ylamino)-2-(5-iodo-2,4-dimethoxybenzoyl)acrylate

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Chemical Property of (S)-ethyl 3-(1-hydroxy-3-methylbutan-2-ylamino)-2-(5-iodo-2,4-dimethoxybenzoyl)acrylate

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Technology Process of (S)-ethyl 3-(1-hydroxy-3-methylbutan-2-ylamino)-2-(5-iodo-2,4-dimethoxybenzoyl)acrylate

There total 4 articles about (S)-ethyl 3-(1-hydroxy-3-methylbutan-2-ylamino)-2-(5-iodo-2,4-dimethoxybenzoyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 2026-48-4,473-75-6
(S)-valinol

: 1598387-88-2
ethyl 3-(5-iodo-2,4-dimethoxyphenyl)-3-oxopropanoate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1598387-94-0
(S)-ethyl 3-(1-hydroxy-3-methylbutan-2-ylamino)-2-(5-iodo-2,4-dimethoxybenzoyl)acrylate

Guidance literature:: ethyl 3-(5-iodo-2,4-dimethoxyphenyl)-3-oxopropanoate; N,N-dimethyl-formamide dimethyl acetal; at 80 ℃; for 4h; Inert atmosphere;

(S)-valinol; In methanol; at 20 ℃; for 2h;

Reference yield:

: 3153-75-1
1-(5-iodo-2,4-dimethoxyphenyl)ethan-1-one

: 1598387-94-0
(S)-ethyl 3-(1-hydroxy-3-methylbutan-2-ylamino)-2-(5-iodo-2,4-dimethoxybenzoyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium 3,7-dimethyloctan-3-olate / tetrahydrofuran; n-heptane / 5 h / 80 °C

2.1: 4 h / 80 °C / Inert atmosphere

2.2: 2 h / 20 °C

With potassium 3,7-dimethyloctan-3-olate; In tetrahydrofuran; n-heptane;

Reference yield:

: 829-20-9
2',4'-dimethoxyacetophenone

: 1598387-94-0
(S)-ethyl 3-(1-hydroxy-3-methylbutan-2-ylamino)-2-(5-iodo-2,4-dimethoxybenzoyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Iodine monochloride / acetonitrile / 4 h / -20 °C / Inert atmosphere

2.1: potassium 3,7-dimethyloctan-3-olate / tetrahydrofuran; n-heptane / 5 h / 80 °C

3.1: 4 h / 80 °C / Inert atmosphere

3.2: 2 h / 20 °C

With potassium 3,7-dimethyloctan-3-olate; Iodine monochloride; In tetrahydrofuran; n-heptane; acetonitrile;