methyl 3(RS),5(SR)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

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Chemical Name:methyl 3(RS),5(SR)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate
CAS No.:124401-30-5
Molecular Formula:C₂₄H₃₂FNO₄
Molecular Weight:417.521
Hs Code.:

Synonyms:methyl 3(RS),5(SR)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

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Chemical Property of methyl 3(RS),5(SR)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

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Technology Process of methyl 3(RS),5(SR)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

There total 11 articles about methyl 3(RS),5(SR)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5153-69-5,706-08-1
4-fluoro-β-nitrostyrene

: 124401-30-5
methyl 3(RS),5(SR)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

Guidance literature:: Multi-step reaction with 7 steps

1: 49.7 percent / methanol / 48 h

2: 77 percent / lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 1 h, 2.) 20 deg C, 1 h

3: 87 percent / N-methylmorpholine N-oxide, tris(triphenylphosphine)ruthenium(II) dichloride / acetone / 20 h / Ambient temperature

4: 1.) sodium hydride / 1.) THF, 0 deg C, 40 min, 2.) RT, 2 h

5: 1.) 1.2 M diisobutylaluminum hydride, 2.) water / 1a.) THF, toluene, 0 deg C, 1 h, 1b.) RT, 1.5 h, 2.) 1 h

7: 1.) 1 M triethylborane, 2.) sodium borohydride / 1.) THF, 20 deg C, 140 min, 2.) -75 deg C, 12 h

With sodium tetrahydroborate; lithium aluminium tetrahydride; tris(triphenylphosphine)ruthenium(II) chloride; triethyl borane; water; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In methanol; diethyl ether; acetone;
DOI:10.1021/jm00163a011

Reference yield:

: 134538-46-8,775-31-5
1-(4-fluorophenyl)-2-nitropropene

: 124401-30-5
methyl 3(RS),5(SR)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

Guidance literature:: Multi-step reaction with 8 steps

1: 50 percent / ethanol / 12 h / Heating

2: 1.) NaH / 1a.) toluene, 60 deg C, 30 min, 1b.) 100 deg C, 10 min, 2.) reflux

3: 75 percent / lithium aluminum hydride / tetrahydrofuran / 20 h / Heating

4: 87 percent / N-methylmorpholine N-oxide, tris(triphenylphosphine)ruthenium(II) dichloride / acetone / 20 h / Ambient temperature

5: 1.) sodium hydride / 1.) THF, 0 deg C, 40 min, 2.) RT, 2 h

6: 1.) 1.2 M diisobutylaluminum hydride, 2.) water / 1a.) THF, toluene, 0 deg C, 1 h, 1b.) RT, 1.5 h, 2.) 1 h

8: 1.) 1 M triethylborane, 2.) sodium borohydride / 1.) THF, 20 deg C, 140 min, 2.) -75 deg C, 12 h

With sodium tetrahydroborate; lithium aluminium tetrahydride; tris(triphenylphosphine)ruthenium(II) chloride; triethyl borane; water; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; ethanol; acetone;
DOI:10.1021/jm00163a011

Reference yield:

: 124401-38-3
4-methyl-3-oxo-N-phenylpentanamide

: 124401-30-5
methyl 3(RS),5(SR)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

Guidance literature:: Multi-step reaction with 9 steps

1: 28.9 g / acetic acid / toluene / 16 h / Heating

2: 50 percent / ethanol / 12 h / Heating

3: 1.) NaH / 1a.) toluene, 60 deg C, 30 min, 1b.) 100 deg C, 10 min, 2.) reflux

4: 75 percent / lithium aluminum hydride / tetrahydrofuran / 20 h / Heating

5: 87 percent / N-methylmorpholine N-oxide, tris(triphenylphosphine)ruthenium(II) dichloride / acetone / 20 h / Ambient temperature

6: 1.) sodium hydride / 1.) THF, 0 deg C, 40 min, 2.) RT, 2 h

7: 1.) 1.2 M diisobutylaluminum hydride, 2.) water / 1a.) THF, toluene, 0 deg C, 1 h, 1b.) RT, 1.5 h, 2.) 1 h

9: 1.) 1 M triethylborane, 2.) sodium borohydride / 1.) THF, 20 deg C, 140 min, 2.) -75 deg C, 12 h

With sodium tetrahydroborate; lithium aluminium tetrahydride; tris(triphenylphosphine)ruthenium(II) chloride; triethyl borane; water; sodium hydride; diisobutylaluminium hydride; acetic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; ethanol; acetone; toluene;
DOI:10.1021/jm00163a011