5-(bis(2-bromoethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(ethylsulfonyl)-2-nitrobenzamide

Base Information

Chemical Name:5-(bis(2-bromoethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(ethylsulfonyl)-2-nitrobenzamide
CAS No.:1563184-62-2
Molecular Formula:C₁₆H₂₃Br₂N₃O₆S
Molecular Weight:545.249
Hs Code.:

Synonyms:5-(bis(2-bromoethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(ethylsulfonyl)-2-nitrobenzamide

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Chemical Property of 5-(bis(2-bromoethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(ethylsulfonyl)-2-nitrobenzamide

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Technology Process of 5-(bis(2-bromoethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(ethylsulfonyl)-2-nitrobenzamide

There total 9 articles about 5-(bis(2-bromoethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(ethylsulfonyl)-2-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1563184-69-9
((5-((2-hydroxyethyl)(methyl)carbamoyl)-2-(ethylsulfonyl)-4-nitrophenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate

: 1563184-62-2
5-(bis(2-bromoethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(ethylsulfonyl)-2-nitrobenzamide

Guidance literature:: With lithium bromide; In acetone; at 20 ℃;

Reference yield:

: 1563184-63-3
4-(ethylsulfonyl)-3-fluorobenzaldehyde

: 1563184-62-2
5-(bis(2-bromoethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(ethylsulfonyl)-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium dihydrogen phosphate monohydrate; dihydrogen peroxide; sodium chlorite; hydrogenchloride / acetonitrile; water / 0 - 20 °C

2.1: sulfuric acid; nitric acid / 4 h / 45 °C

3.1: perchloric acid / 20 °C

4.1: dimethyl sulfoxide / 2 h / 20 °C

5.1: triethylamine / dichloromethane / 0.33 h / 0 °C

6.1: trifluoroacetic acid / dichloromethane / 5 - 20 °C

7.1: N,N-dimethyl-formamide; magnesium oxide; oxalyl dichloride / dichloromethane; acetonitrile / 4 h / 0 - 20 °C

7.2: 0.33 h / 0 - 20 °C

8.1: lithium bromide / acetone / 20 °C

With hydrogenchloride; sodium chlorite; perchloric acid; sodium dihydrogen phosphate monohydrate; oxalyl dichloride; sulfuric acid; dihydrogen peroxide; nitric acid; magnesium oxide; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; lithium bromide; In dichloromethane; water; dimethyl sulfoxide; acetone; acetonitrile;

Reference yield:

: 1563184-64-4
4-(ethylsulfonyl)-5-fluoro-2-nitrobenzoic acid

: 1563184-62-2
5-(bis(2-bromoethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(ethylsulfonyl)-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: perchloric acid / 20 °C

2.1: dimethyl sulfoxide / 2 h / 20 °C

3.1: triethylamine / dichloromethane / 0.33 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 5 - 20 °C

5.1: N,N-dimethyl-formamide; magnesium oxide; oxalyl dichloride / dichloromethane; acetonitrile / 4 h / 0 - 20 °C

5.2: 0.33 h / 0 - 20 °C

6.1: lithium bromide / acetone / 20 °C

With perchloric acid; oxalyl dichloride; magnesium oxide; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; lithium bromide; In dichloromethane; dimethyl sulfoxide; acetone; acetonitrile;