N-(4-(4-amino-1-(1-(3-(3-fluorophenyl)-4-oxo-4H-chromen-2-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetamide

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Chemical Name:N-(4-(4-amino-1-(1-(3-(3-fluorophenyl)-4-oxo-4H-chromen-2-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetamide
CAS No.:1300585-10-7
Molecular Formula:C₃₀H₂₃FN₆O₃
Molecular Weight:534.549
Hs Code.:

Synonyms:N-(4-(4-amino-1-(1-(3-(3-fluorophenyl)-4-oxo-4H-chromen-2-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetamide

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Chemical Property of N-(4-(4-amino-1-(1-(3-(3-fluorophenyl)-4-oxo-4H-chromen-2-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetamide

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Technology Process of N-(4-(4-amino-1-(1-(3-(3-fluorophenyl)-4-oxo-4H-chromen-2-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetamide

There total 7 articles about N-(4-(4-amino-1-(1-(3-(3-fluorophenyl)-4-oxo-4H-chromen-2-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1300583-90-7
2-(1-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

: 101251-09-6
(4-acetylaminophenyl)boronic acid

: 1300585-10-7
N-(4-(4-amino-1-(1-(3-(3-fluorophenyl)-4-oxo-4H-chromen-2-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide; at 80 ℃; for 12.5h; Inert atmosphere;

Reference yield:

: 331-25-9
(3-fluorophenyl)acetic acid

: 1300585-10-7
N-(4-(4-amino-1-(1-(3-(3-fluorophenyl)-4-oxo-4H-chromen-2-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

1.2: 0 °C

2.1: triethylamine / 24 h / Reflux

3.1: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / Reflux

4.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 12 h / 80 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 12 h

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; ethanol; water / 12.5 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); ammonium formate; sodium carbonate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 6.1: Suzuki Coupling;

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 1300585-10-7
N-(4-(4-amino-1-(1-(3-(3-fluorophenyl)-4-oxo-4H-chromen-2-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

1.2: 0 °C

2.1: triethylamine / 24 h / Reflux

3.1: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / Reflux

4.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 12 h / 80 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 12 h

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; ethanol; water / 12.5 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); ammonium formate; sodium carbonate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 6.1: Suzuki Coupling;