tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-(methylamino)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

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Chemical Name:tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-(methylamino)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate
CAS No.:1610697-89-6
Molecular Formula:C₂₄H₂₃Cl₂N₅O₂
Molecular Weight:484.385
Hs Code.:

Synonyms:tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-(methylamino)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

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Chemical Property of tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-(methylamino)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

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Technology Process of tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-(methylamino)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

There total 8 articles about tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-(methylamino)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1610697-88-5
tert-butyl 7-(3-aminophenyl)-6-chloro-5-(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

: 1610697-89-6
tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-(methylamino)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

Guidance literature:: formaldehyd; tert-butyl 7-(3-aminophenyl)-6-chloro-5-(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate; In tetrahydrofuran; water; at 20 ℃; Molecular sieve;

With sodium cyanoborohydride; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield:

: 13331-27-6
m-nitrobenzene boronic acid

: 1610697-89-6
tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-(methylamino)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper diacetate; pyridine / dichloromethane / 120 h / 20 °C / Molecular sieve

2.1: ammonium hydroxide / 1,4-dioxane / 1 h / 120 °C / Sealed tube

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere

6.1: iron; ammonium chloride / water; tetrahydrofuran; ethanol / 8 h / 50 °C / Inert atmosphere

7.1: water; tetrahydrofuran / 20 °C / Molecular sieve

7.2: 1 h / 20 °C

With pyridine; ammonium hydroxide; N-chloro-succinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper diacetate; iron; sodium carbonate; ammonium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1422828-21-4
4-chloro-5-iodo-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidine

: 1610697-89-6
tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-(methylamino)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium hydroxide / 1,4-dioxane / 1 h / 120 °C / Sealed tube

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere

5.1: iron; ammonium chloride / water; tetrahydrofuran; ethanol / 8 h / 50 °C / Inert atmosphere

6.1: water; tetrahydrofuran / 20 °C / Molecular sieve

6.2: 1 h / 20 °C

With ammonium hydroxide; N-chloro-succinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iron; sodium carbonate; ammonium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;