tert-Butyl-((S)-5-methoxy-tetrahydro-furan-2-ylmethoxy)-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-((S)-5-methoxy-tetrahydro-furan-2-ylmethoxy)-dimethyl-silane
CAS No.:185303-79-1
Molecular Formula:C₁₂H₂₆O₃Si
Molecular Weight:246.422
Hs Code.:

Synonyms:tert-Butyl-((S)-5-methoxy-tetrahydro-furan-2-ylmethoxy)-dimethyl-silane

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Chemical Property of tert-Butyl-((S)-5-methoxy-tetrahydro-furan-2-ylmethoxy)-dimethyl-silane

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Technology Process of tert-Butyl-((S)-5-methoxy-tetrahydro-furan-2-ylmethoxy)-dimethyl-silane

There total 1 articles about tert-Butyl-((S)-5-methoxy-tetrahydro-furan-2-ylmethoxy)-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 185303-79-1
tert-Butyl-((S)-5-methoxy-tetrahydro-furan-2-ylmethoxy)-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / imidazole / CH₂Cl₂ / 3 h

2: DIBAL-H / CH₂Cl₂; toluene / 2 h / -90 °C

3: molecular sieves (4 Angstroem), BF₃*OEt₂ / diethyl ether / 0.5 h

With 1H-imidazole; 4 A molecular sieve; boron trifluoride diethyl etherate; diisobutylaluminium hydride; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm960400q

Reference yield:

: 185303-79-1
tert-Butyl-((S)-5-methoxy-tetrahydro-furan-2-ylmethoxy)-dimethyl-silane

: 5983-09-5,153547-98-9
2',3'-Dideoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1,1,1,3,3,3-heksamethylenedisilazane, ammonium sulfate, 2.) SnCl₄, TMSOTf / 1.) reflux, 2 h, 2.) 1,2-dichloroethane, RT, 2 h

2: TBAF / tetrahydrofuran / 8 h / Ambient temperature

With ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran;
DOI:10.1021/jm960400q

Reference yield:

: 185303-79-1
tert-Butyl-((S)-5-methoxy-tetrahydro-furan-2-ylmethoxy)-dimethyl-silane

: 121154-54-9,153547-98-9
2',3'-dideoxy-α-D-uridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1,1,1,3,3,3-heksamethylenedisilazane, ammonium sulfate, 2.) SnCl₄, TMSOTf / 1.) reflux, 2 h, 2.) 1,2-dichloroethane, RT, 2 h

2: TBAF / tetrahydrofuran / 8 h / Ambient temperature

With ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran;
DOI:10.1021/jm960400q