Vinyl-phosphonic acid 2-cyano-ethyl ester (2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

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Chemical Name:Vinyl-phosphonic acid 2-cyano-ethyl ester (2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester
CAS No.:127924-73-6
Molecular Formula:C₃₃H₃₈NO₈P
Molecular Weight:607.64
Hs Code.:

Synonyms:Vinyl-phosphonic acid 2-cyano-ethyl ester (2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

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Chemical Property of Vinyl-phosphonic acid 2-cyano-ethyl ester (2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

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Technology Process of Vinyl-phosphonic acid 2-cyano-ethyl ester (2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

There total 3 articles about Vinyl-phosphonic acid 2-cyano-ethyl ester (2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 127924-72-5
(2-Bromo-ethyl)-phosphonic acid 2-cyano-ethyl ester (2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

: 127924-73-6
Vinyl-phosphonic acid 2-cyano-ethyl ester (2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 4h;
DOI:10.1016/S0040-4039(01)80597-9

Reference yield:

: 40653-32-5,641635-63-4
methyl 2,3,4-tri-O-benzyl-β-D-galactopyranoside

: 127924-73-6
Vinyl-phosphonic acid 2-cyano-ethyl ester (2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 0.17 h

2: 75 percent / 4 h / 20 °C

3: 85 percent / Et₃N / acetonitrile / 4 h / 20 °C

With triethylamine; In acetonitrile;
DOI:10.1016/S0040-4039(01)80597-9

Reference yield:

: 127924-71-4
(2-Bromo-ethyl)-phosphonic acid benzotriazol-1-yl ester (2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

: 127924-73-6
Vinyl-phosphonic acid 2-cyano-ethyl ester (2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / 4 h / 20 °C

2: 85 percent / Et₃N / acetonitrile / 4 h / 20 °C

With triethylamine; In acetonitrile;
DOI:10.1016/S0040-4039(01)80597-9