(S)-Meclizine

Base Information

Chemical Name:(S)-Meclizine
CAS No.:189298-47-3
Molecular Formula:C₂₅H₂₇ClN₂
Molecular Weight:390.956
Hs Code.:
UNII:LV0F32NYUF
Wikidata:Q27283196
ChEMBL ID:CHEMBL1440522
Mol file:189298-47-3.mol

Synonyms:(S)-Meclizine;Meclizine, (S)-;Meclozine, (S)-;LV0F32NYUF;UNII-LV0F32NYUF;189298-47-3;Piperazine, 1-((S)-(4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-;Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-, (S)-;1-[(S)-(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;NCGC00016563-01;CAS-1104-22-9;SCHEMBL4650;CHEMBL1440522;NCGC00018296-01;NCGC00018296-03;PD132478;Q27283196

Suppliers and Price of (S)-Meclizine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (S)-Meclizine

Chemical Property:

PSA：6.48000
LogP:5.43140
XLogP3:5.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:390.1862766
Heavy Atom Count:28
Complexity:448

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl
Isomeric SMILES:CC1=CC(=CC=C1)CN2CCN(CC2)[C@@H](C3=CC=CC=C3)C4=CC=C(C=C4)Cl

Technology Process of (S)-Meclizine

There total 10 articles about (S)-Meclizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: sodium hydroxy(m-tolyl)methanesulfonate

: 569-65-3,163837-49-8,163837-50-1,189298-48-4,189298-47-3
meclizine

Guidance literature:: With 2-picoline borane complex; In methanol; water; at 60 ℃; for 6h; Sealed tube; Inert atmosphere;
DOI:10.1021/acs.orglett.1c02604

Reference yield: 87.0%

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 4-nitrophenyl bis(carbomethoxy) 3-(3-methylbenzyl)ylide

: 569-65-3,163837-49-8,163837-50-1,189298-48-4,189298-47-3
meclizine

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; at 20 ℃; for 24h; Molecular sieve;
DOI:10.1016/j.cclet.2021.06.069

Reference yield: 87.0%

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 620-23-5
m-tolyl aldehyde

: 569-65-3,163837-49-8,163837-50-1,189298-48-4,189298-47-3
meclizine

Guidance literature:: With formic acid; boron trifluoride diethyl etherate; In acetonitrile; at 85 ℃; for 5h; Green chemistry;
DOI:10.1039/d1gc01468d