rac-6-chloro-3-(3-chloro-benzyl)-3-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-1,3-dihydro-indol-2-one

Base Information

Chemical Name:rac-6-chloro-3-(3-chloro-benzyl)-3-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-1,3-dihydro-indol-2-one
CAS No.:1015685-46-7
Molecular Formula:C₂₆H₂₂Cl₂F₃N₃O
Molecular Weight:520.381
Hs Code.:

Synonyms:rac-6-chloro-3-(3-chloro-benzyl)-3-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-1,3-dihydro-indol-2-one

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Chemical Property of rac-6-chloro-3-(3-chloro-benzyl)-3-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-1,3-dihydro-indol-2-one

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Technology Process of rac-6-chloro-3-(3-chloro-benzyl)-3-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-1,3-dihydro-indol-2-one

There total 5 articles about rac-6-chloro-3-(3-chloro-benzyl)-3-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-1,3-dihydro-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917918-15-1
rac-3-bromo-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one

: 30459-17-7
1-[4-(trifluoromethyl)phenyl]piperazine

: 1015685-46-7
rac-6-chloro-3-(3-chloro-benzyl)-3-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-1,3-dihydro-indol-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

Reference yield:

: 56341-37-8
6-chloro-2-oxindole

: 1015685-46-7
rac-6-chloro-3-(3-chloro-benzyl)-3-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-1,3-dihydro-indol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: pyrrolidine / methanol / 3 h / 70 °C

2: sodium tetrahydroborate / methanol; dimethyl sulfoxide / 0.5 - 1 h / 20 °C

3: pyridinium hydrobromide perbromide / water; tert-butyl alcohol / 4 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With pyrrolidine; sodium tetrahydroborate; pyridinium hydrobromide perbromide; N-ethyl-N,N-diisopropylamine; In methanol; water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 917917-78-3
rac-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one

: 1015685-46-7
rac-6-chloro-3-(3-chloro-benzyl)-3-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-1,3-dihydro-indol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium hydrobromide perbromide / water; tert-butyl alcohol / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With pyridinium hydrobromide perbromide; N-ethyl-N,N-diisopropylamine; In water; acetonitrile; tert-butyl alcohol;