11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

Base Information

• Chemical Name: 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)
• CAS No.: 126559-84-0
• Molecular Formula: C₃₄H₄₀O₃
• Molecular Weight: 496.69
• Mol file: 126559-84-0.mol

Synonyms:11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

Chemical Property of 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

There total 4 articles about 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

11β-(1-ethenyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether) (129000-34-6) → 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether) (126559-84-0)

Guidance literature:

11β-(1-ethenyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether); With lithium borohydride; benzo[1,3,2]dioxaborole; In tetrahydrofuran; at 20 ℃; for 21h;

With sodium hydroxide; dihydrogen peroxide; In ethanol; at 20 ℃; for 6h;

DOI:10.1021/jm049352x

Reference yield:

11beta-Vinylestradiol (68599-01-9) → 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether) (126559-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98.5 percent / sodium hydride / dimethylformamide / 16 h / Ambient temperature

2: 1.) borane-dimethyl sulfide complex, 2.) 3 N aq. NaOH, 30percent aq. H₂O₂ / 1.) hexane, benzene, from 0 deg C to RT, 3 h, 2.) hexane, benzene, ethanol, reflux, 1 h

With sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00174a010

Reference yield:

Acetic acid (8S,9S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-vinyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester → 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether) (126559-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / 10 N aq. NaOH / methanol / 7 h / Ambient temperature

2: 98.5 percent / sodium hydride / dimethylformamide / 16 h / Ambient temperature

3: 1.) borane-dimethyl sulfide complex, 2.) 3 N aq. NaOH, 30percent aq. H₂O₂ / 1.) hexane, benzene, from 0 deg C to RT, 3 h, 2.) hexane, benzene, ethanol, reflux, 1 h

With sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00174a010

upstream raw materials:

11β-(1-ethenyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

11beta-Vinylestradiol

11β-vinylestrone 3-acetate

Downstream raw materials:

C₃₆H₄₂O₃

C₃₆H₄₂O₄

3,17β-dibenzyloxy-11β-(2-propoxyethyl)estra-1,3,5(10)-triene

3,17β-dibenzyloxy-11β-(2-ethoxyethyl)estra-1,3,5(10)-triene