11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

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Chemical Name:11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)
CAS No.:126559-84-0
Molecular Formula:C₃₄H₄₀O₃
Molecular Weight:496.69
Hs Code.:

Synonyms:11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

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Chemical Property of 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

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Technology Process of 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

There total 4 articles about 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 129000-34-6
11β-(1-ethenyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

: 126559-84-0
11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

Guidance literature:: 11β-(1-ethenyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether); With lithium borohydride; benzo[1,3,2]dioxaborole; In tetrahydrofuran; at 20 ℃; for 21h;

With sodium hydroxide; dihydrogen peroxide; In ethanol; at 20 ℃; for 6h;
DOI:10.1021/jm049352x

Reference yield:

: 68599-01-9
11beta-Vinylestradiol

: 126559-84-0
11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

Guidance literature:: Multi-step reaction with 2 steps

1: 98.5 percent / sodium hydride / dimethylformamide / 16 h / Ambient temperature

2: 1.) borane-dimethyl sulfide complex, 2.) 3 N aq. NaOH, 30percent aq. H₂O₂ / 1.) hexane, benzene, from 0 deg C to RT, 3 h, 2.) hexane, benzene, ethanol, reflux, 1 h

With sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00174a010

Reference yield:

: Acetic acid (8S,9S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-vinyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester

: 126559-84-0
11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / 10 N aq. NaOH / methanol / 7 h / Ambient temperature

2: 98.5 percent / sodium hydride / dimethylformamide / 16 h / Ambient temperature

3: 1.) borane-dimethyl sulfide complex, 2.) 3 N aq. NaOH, 30percent aq. H₂O₂ / 1.) hexane, benzene, from 0 deg C to RT, 3 h, 2.) hexane, benzene, ethanol, reflux, 1 h

With sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; sodium hydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00174a010