2-<<2-bromo-4-(1-methylethyl)phenyl>amino>-5-<6-(1H-imidazol-1-yl)hexyl>pyridine

Base Information

Chemical Name:2-<<2-bromo-4-(1-methylethyl)phenyl>amino>-5-<6-(1H-imidazol-1-yl)hexyl>pyridine
CAS No.:107962-20-9
Molecular Formula:C₂₃H₂₉BrN₄
Molecular Weight:441.414
Hs Code.:

Synonyms:2-<<2-bromo-4-(1-methylethyl)phenyl>amino>-5-<6-(1H-imidazol-1-yl)hexyl>pyridine

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Chemical Property of 2-<<2-bromo-4-(1-methylethyl)phenyl>amino>-5-<6-(1H-imidazol-1-yl)hexyl>pyridine

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Technology Process of 2-<<2-bromo-4-(1-methylethyl)phenyl>amino>-5-<6-(1H-imidazol-1-yl)hexyl>pyridine

There total 9 articles about 2-<<2-bromo-4-(1-methylethyl)phenyl>amino>-5-<6-(1H-imidazol-1-yl)hexyl>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 107962-18-5
5-<6-(1H-imidazol-1-yl)hexyl>-2-<<4-(1-methylethyl)phenyl>amino>pyridine

: 107962-20-9
2-<<2-bromo-4-(1-methylethyl)phenyl>amino>-5-<6-(1H-imidazol-1-yl)hexyl>pyridine

Guidance literature:: With bromine; sodium acetate; In acetic acid; for 1h;
DOI:10.1021/jo00388a023

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 107962-20-9
2-<<2-bromo-4-(1-methylethyl)phenyl>amino>-5-<6-(1H-imidazol-1-yl)hexyl>pyridine

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / 2 h / 160 - 180 °C

2: 100 percent / acetic acid / 3 h / Heating

3: 92 percent / triethylamine, bis(triphenylphosphine)palladium chloride, cuprous iodide / CH₂Cl₂ / 5 h / Heating

4: 86 percent / H₂ / platinum oxide / ethanol

5: Et₃N / CH₂Cl₂ / 1 h / 0 °C

6: sodium hydride / dimethylformamide / 2 h / 60 °C

7: 87 percent / 6 N HCl / 24 h / Heating

8: 84 percent / sodium acetate, bromine / acetic acid / 1 h

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; bromine; sodium acetate; sodium hydride; triethylamine; platinum(IV) oxide; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00388a023

Reference yield:

: 99-88-7
4-Isopropylaniline

: 107962-20-9
2-<<2-bromo-4-(1-methylethyl)phenyl>amino>-5-<6-(1H-imidazol-1-yl)hexyl>pyridine

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / 2 h / 160 - 180 °C

2: 100 percent / acetic acid / 3 h / Heating

3: 92 percent / triethylamine, bis(triphenylphosphine)palladium chloride, cuprous iodide / CH₂Cl₂ / 5 h / Heating

4: 86 percent / H₂ / platinum oxide / ethanol

5: Et₃N / CH₂Cl₂ / 1 h / 0 °C

6: sodium hydride / dimethylformamide / 2 h / 60 °C

7: 87 percent / 6 N HCl / 24 h / Heating

8: 84 percent / sodium acetate, bromine / acetic acid / 1 h

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; bromine; sodium acetate; sodium hydride; triethylamine; platinum(IV) oxide; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00388a023