2-(2-(4-(hydroxy(4-(trifluoromethyl)phenyl)methyl)pyridin-3-yl)ethyl)-isoindoline-1,3-dione

Base Information

Chemical Name:2-(2-(4-(hydroxy(4-(trifluoromethyl)phenyl)methyl)pyridin-3-yl)ethyl)-isoindoline-1,3-dione
CAS No.:1133853-78-7
Molecular Formula:C₂₃H₁₇F₃N₂O₃
Molecular Weight:426.395
Hs Code.:

Synonyms:2-(2-(4-(hydroxy(4-(trifluoromethyl)phenyl)methyl)pyridin-3-yl)ethyl)-isoindoline-1,3-dione

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Chemical Property of 2-(2-(4-(hydroxy(4-(trifluoromethyl)phenyl)methyl)pyridin-3-yl)ethyl)-isoindoline-1,3-dione

Chemical Property:

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Technology Process of 2-(2-(4-(hydroxy(4-(trifluoromethyl)phenyl)methyl)pyridin-3-yl)ethyl)-isoindoline-1,3-dione

There total 4 articles about 2-(2-(4-(hydroxy(4-(trifluoromethyl)phenyl)methyl)pyridin-3-yl)ethyl)-isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1133853-77-6
(E)-2-(2-(4-(hydroxy(4-(trifluoromethyl)phenyl)methyl)pyridin-3-yl)vinyl)-isoindoline-1,3-dione

: 1133853-78-7
2-(2-(4-(hydroxy(4-(trifluoromethyl)phenyl)methyl)pyridin-3-yl)ethyl)-isoindoline-1,3-dione

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 12h; under 760.051 Torr;

Reference yield:

: 402-43-7
p-trifluoromethylphenyl bromide

: 1133853-78-7
2-(2-(4-(hydroxy(4-(trifluoromethyl)phenyl)methyl)pyridin-3-yl)ethyl)-isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; iodine / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux

1.2: 2 h / 20 °C / Inert atmosphere

2.1: triethylamine; CyJohnPhos; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 150 °C

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; iodine; magnesium; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; CyJohnPhos; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; 2.1: |Heck Reaction;
DOI:10.1021/jm401955h

Reference yield:

: 1133853-76-5
(3-bromopyridin-4-yl)-(4-(trifluoromethyl)phenyl)methanol

: 1133853-78-7
2-(2-(4-(hydroxy(4-(trifluoromethyl)phenyl)methyl)pyridin-3-yl)ethyl)-isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; CyJohnPhos; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 150 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; CyJohnPhos; In ethyl acetate; N,N-dimethyl-formamide; 1: |Heck Reaction;
DOI:10.1021/jm401955h