2-(3-((2R,3R,4R,5R)-3,4-bis(tert-butoxycarbonyloxy)-5-((tert-butoxycarbonyloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

Base Information

Chemical Name:2-(3-((2R,3R,4R,5R)-3,4-bis(tert-butoxycarbonyloxy)-5-((tert-butoxycarbonyloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate
CAS No.:1054489-48-3
Molecular Formula:C₃₄H₄₈N₂O₁₅S
Molecular Weight:756.826
Hs Code.:

2-(3-((2R,3R,4R,5R)-3,4-bis(tert-butoxycarbonyloxy)-5-((tert-butoxycarbonyloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

Synonyms:2-(3-((2R,3R,4R,5R)-3,4-bis(tert-butoxycarbonyloxy)-5-((tert-butoxycarbonyloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

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Chemical Property of 2-(3-((2R,3R,4R,5R)-3,4-bis(tert-butoxycarbonyloxy)-5-((tert-butoxycarbonyloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

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Technology Process of 2-(3-((2R,3R,4R,5R)-3,4-bis(tert-butoxycarbonyloxy)-5-((tert-butoxycarbonyloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

There total 9 articles about 2-(3-((2R,3R,4R,5R)-3,4-bis(tert-butoxycarbonyloxy)-5-((tert-butoxycarbonyloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: C₂₇H₄₂N₂O₁₃

: 4124-41-8
p-toluenesulfonylanhydride

: 1054489-48-3
2-(3-((2R,3R,4R,5R)-3,4-bis(tert-butoxycarbonyloxy)-5-((tert-butoxycarbonyloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

Guidance literature:: With triethylamine; In dichloromethane; for 2h;

Reference yield:

: 1054489-43-8
C₁₉H₂₄N₂O₇

: 1054489-48-3
2-(3-((2R,3R,4R,5R)-3,4-bis(tert-butoxycarbonyloxy)-5-((tert-butoxycarbonyloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dmap / tetrahydrofuran / 2 h / Heating / reflux

2: hydrogen / palladium on activated charcoal / ethanol; ethyl acetate / 4 h / 2585.81 Torr

3: triethylamine / dichloromethane / 2 h

With hydrogen; triethylamine; dmap; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 1054489-41-6
C₂₆H₂₇BrN₂O₈

: 1054489-48-3
2-(3-((2R,3R,4R,5R)-3,4-bis(tert-butoxycarbonyloxy)-5-((tert-butoxycarbonyloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia; water / methanol / 5 h

2: triethylamine / dmap / tetrahydrofuran / 2 h / Heating / reflux

3: hydrogen / palladium on activated charcoal / ethanol; ethyl acetate / 4 h / 2585.81 Torr

4: triethylamine / dichloromethane / 2 h

With ammonia; water; hydrogen; triethylamine; dmap; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;